Synthesis and SAR of thioester and thiol inhibitors of IMP-1 metallo-beta-lactamase.

Bioorg Med Chem Lett

Department of Medicinal Chemistry, Merck Research Laboratorie, Rahway, NJ 07065, USA.

Published: September 1999

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Potent thioester and thiol inhibitors of IMP-1 metallo-beta-lactamase have been synthesized employing a solid-phase Mitsunobu reaction as the key step.

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http://dx.doi.org/10.1016/s0960-894x(99)00425-4DOI Listing

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