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http://dx.doi.org/10.1212/wnl.53.5.1154DOI Listing

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Article Synopsis
  • Chronic hand eczema (CHE) is a common skin condition that is hard to treat, but the drug dupilumab, known for treating atopic dermatitis, shows promise for CHE as well.
  • A review of 22 studies involving 374 patients revealed that 80.3% experienced partial or complete improvement within 4-16 weeks of starting dupilumab, with effects often lasting beyond the studies.
  • While dupilumab proved effective for various CHE subtypes, it was particularly successful for dyshidrotic and vesicular forms, but less so for hyperkeratotic eczema; the most common side effects included conjunctivitis and mild skin reactions.
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Article Synopsis
  • Scientists studied skin conditions called vesicular hand eczema (VHE) and atopic dermatitis (AD) to find out how they are similar and different.
  • They looked at genes in skin samples from both conditions and found many genes that were active in both types of eczema, but also some that were unique to VHE.
  • The results showed VHE has some different features and signaling processes compared to AD, suggesting they might be related but also have their own unique traits.
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Darier Disease Presenting with Recurrent Kaposi Varicelliform Eruption in a 10-year-old Boy with Seborrheic Dermatitis.

Acta Dermatovenerol Croat

November 2021

Marta Navratil, MD, PhD, Department of Pulmonology, Allergology, Rheumatology and Clinical Immunology, Children's Hospital Zagreb, Klaićeva 16, 10000 Zagreb, Croatia;

Article Synopsis
  • A 10-year-old boy with seborrheic dermatitis (SD) was referred for recurring Kaposi varicelliform eruption (KVE) linked to herpes simplex virus (HSV-1) and possible primary immunodeficiency.
  • He has a history of skin issues since infancy, and his family has no known history of skin disorders or immunodeficiency, although he does have a sensory processing disorder.
  • Medical evaluations revealed normal immunoglobulin levels but a lower T-cell count, leading to a diagnosis of Darier disease (DD) after unsuccessful treatments for his skin flare-ups.
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Dyshidrotic eczema (DE) or acute palmoplantar eczema is a common cause of hand and foot dermatitis in adults. It is a recurrent vesicular eruption affecting the soles, palms, or both. It is very pruriginous and generally appears suddenly.

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