Background: Genetic factors are involved in the development of diabetic nephropathy in Type 1 diabetes. We have examined the association of four candidate genes, angiotensin converting enzyme (ACE): insertion/deletion (I/D) polymorphism, plasminogen activator inhibitor-1 (PAI-1): 4G/5G polymorphism, decorin: 179/183/185 polymorphism and Werner syndrome helicase: C/R polymorphism, with the presence of diabetic nephropathy in Type 1 diabetic patients.
Methods: 175 Type 1 diabetic patients with albuminuria (59 with microalbuminuria and 116 with macroalbuminuria) were compared with 136 Type 1 diabetic patients with normoalbuminuria and duration of disease longer than 15 years (mean+/-SD: 25+/-8 years). 200 non-diabetic subjects were also studied as background population.
Results: We found no association in the polymorphism of the four genes examined between patients with and without diabetic nephropathy and the control subjects.
Conclusions: The genes studied are unlikely to be involved in the susceptibility to nephropathy in Type 1 diabetic patients.
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| http://dx.doi.org/10.1002/(sici)1520-7560(199907/08)15:4<247::aid-dmrr41>3.0.co;2-p | DOI Listing |
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