Parathyroid hormone messenger RNA levels are regulated by calcium, phosphate and 1,25-dihydroxyvitamin D3. Dietary induced hypocalcaemia increases and hypophosphataemia decreases parathyroid hormone mRNA levels post-transcriptionally. This regulation is mediated by binding of parathyroid cytosolic proteins to the parathyroid hormone mRNA 3'-untranslated region, and in particular the terminal 60 nucleotides of the 3'-untranslated region, thereby determining RNA stability.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/00041552-199907000-00004 | DOI Listing |
Publication Analysis
Top Keywords
parathyroid hormone
16
calcium phosphate
8
hormone mrna
8
3'-untranslated region
8
parathyroid
5
post-transcriptional regulation
4
regulation parathyroid
4
hormone
4
hormone gene
4
gene calcium
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!