AI Article Synopsis
- A murine alpha4 protein, found in lymphocytes, interacts with protein phosphatase 2A (PP2A) and has a related gene called alpha4-b.
- The alpha4-b gene is specifically expressed in the brain and testis, with no detection in other organs like the spleen or liver.
- Alpha4-b is present in most neuronal cells but absent in glial cells, and it encodes a protein that is 66% similar to alpha4, indicating a role in regulating phosphatase activity in neurons.
Article Abstract
A murine alpha4, identified in lymphocytes, binds to protein phosphatase 2A (PP2A). We found another murine alpha4-related gene (named alpha4-b) expressed selectively in the brain and testis. The alpha4-b transcript is expressed in the brain and testis, but is not detected in the spleen, thymus, bone marrow, liver, kidney, lung, heart or muscle. In-situ RNA hybridization analysis suggested that alpha4-b is expressed in most neuronal cells in the brain, but it is not expressed in the glial cells. The alpha4-b cDNA encodes a putative protein that is highly homologous (66% identity in amino-acid sequence) to the alpha4 molecule. The alpha4-b protein associates with the catalytic subunit of PP2A (PP2Ac), suggesting that the alpha4-b protein is involved in the regulation of phosphatase activity in neuronal cells.
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| http://dx.doi.org/10.1046/j.1432-1327.1999.00571.x | DOI Listing |
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