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Antibiotic chemoprophylaxis for close contacts of invasive group A streptococcus in community settings: evidence review.
J Infect
March 2025
UK Health Security Agency, Field Services North West, Liverpool, L1 3DS. Electronic address:
Objectives: Revised UK guidelines for the management of contacts of invasive group A Streptococcus (iGAS) infection in community settings were published in December 2022. We present the findings of a narrative review which informed the public health recommendations around the provision of antibiotic chemoprophylaxis detailed in the updated guidelines.
Methods: We conducted a literature review of studies reporting the risk of iGAS infection associated with specific risk factors.
Frequency, Severity and Impact of Pegylated Interferon Alpha-Associated Flares in Hepatitis D Infection.
J Viral Hepat
April 2025
Department of Gastroenterology, Hepatology, Infectious Diseases, and Endocrinology, Hannover Medical School, Hannover, Germany.
We analysed the frequency, severity and impact of hepatitis flares in a large Phase 2 study investigating pegylated interferon-alfa-2a (PEG-IFNa) for the treatment of hepatitis D. In the HIDIT-II study, 120 patients were treated for 96 weeks with PEG-IFNa (180 μg weekly) in combination with tenofovir disoproxil fumarate (TDF, 300 mg once daily) or placebo. Hepatitis flares were defined as ALT increases above 10 times the upper limit of normal or increases of more than 2.
View Article and Find Full Text PDFA population-representative serosurvey estimating vaccine-induced immunity against measles, rubella, hepatitis B and severe acute respiratory syndrome coronavirus 2 in Timor-Leste.
Lancet Reg Health Southeast Asia
March 2025
Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Dili, Timor-Leste.
Background: Serosurveillance can be used to assess population immunity to vaccine-preventable diseases (VPDs). This study aimed to determine seroprevalence of four VPDs across Timor-Leste and identify immunity gaps.
Methods: A population-representative three-stage cluster random sample of census-enumerated households were visited between October 2021 and February 2023.
Waldenström Macroglobulinemia - A State-of-the-Art Review: Part 2- Focus on Therapy.
Mediterr J Hematol Infect Dis
March 2025
Bing Center for Waldenström's Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA, USA.
Unlabelled: The diagnosis and treatment of Waldenstrom macroglobulinemia (WM) are the subjects of this two-part review, which aims to provide current and thorough knowledge of these topics. The first portion of the study, previously published, investigated the epidemiology, etiology, clinicopathological aspects, differential diagnosis, prognostic factors, and impact on WM-specific groups. Specifically, this second section examines both the standard consolidated method and the new therapeutic strategy to handle the complex topic of the treatment of WM.
View Article and Find Full Text PDFPopulation-based estimates of hepatitis E virus associated mortality in Bangladesh.
J Infect Dis
March 2025
icddr,b, Dhaka, Bangladesh.
Background: Hepatitis E virus (HEV) is endemic in many resource-poor countries. Despite an available vaccine, data on HEV-associated mortality are scarce, hindering informed decisions. This study aims to estimate the population-based rate of HEV-specific mortality in Bangladesh.
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