[Multiple and bilateral nodular opacities revealing primary pulmonary lymphoma of the Burkitt-like type in AIDS].

Rev Pneumol Clin

Service de Médecine Interne et des Maladies Infectieuses, Hôpital de la Conception, Marseille, France.

Published: June 1999

AI Article Synopsis

  • A case is reported involving an AIDS patient who presented with respiratory symptoms and bilateral nodular opacities on chest X-ray, initially suspected to be infectious, but treatment was unsuccessful.
  • A lung biopsy revealed the rare diagnosis of primary pulmonary Burkitt's-like lymphoma (BBL), highlighting an unusual occurrence in AIDS patients as this type of lymphoma typically appears earlier in HIV infection.
  • The study underscores the complexity of diagnosing respiratory issues in immunocompromised patients and points to the severe prognosis associated with AIDS-related BBL.

Article Abstract

We report the observation of AIDS patient with a history of cough, dyspnea, fever, cachexia and bilateral nodular opacities at the chest X-ray. Infectious etiologies were initially suspected but the recovery was not obtained with their treatment. Only lung biopsy established the precise diagnosis of primary pulmonary Burkitt's-like lymphoma (BBL). The sole extranodal site of BBL at the lungs is an unusual finding. Generally, this lymphomatous proliferation is observed at the early period of the HIV infection. Immunodepression and Epstein-Barr virus (EBV) infection are the major pathogenic basis for BL as indicated by the high prevalence of EBV genomes found in malignant cells. The lack of EBV sequences in a significant proportion of Burkitt's lymphoma or BBL and AIDS-associated non-Hodgkin malignant lymphoma suggest that alternative pathogenic mechanisms may be involved. This observation permit to show the difficulties observed before the multiple and bilateral opacities whom the etiologies are varied. The prognosis of AIDS-associated BLL is very severe.

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