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Effect of long and short half-life PDE5 inhibitors on HbA1c levels: a systematic review and meta-analysis.
EClinicalMedicine
February 2025
Human Stem Cell and Genome Engineering Center, University of California Los Angeles David Geffen School of Medicine, UCLA - CHS 36 - 125/133/143 650 Charles E. Young Dr. South, Los Angeles, CA, 90095, USA.
Background: Phosphodiesterase 5 (PDE5) inhibitors, owing to their mechanism of action, have been gaining recognition as a potential case of drug repurposing and combination therapy for diabetes treatment. We aimed to examine the effect of long and short half-life PDE5 inhibitors have on Haemoglobin A1c (HbA1c) levels.
Methods: A systematic review and meta-analysis was conducted of randomised controlled trials (RCTs) in people with elevated HbA1c (>6%) to assess mean difference in HbA1c levels from baseline versus controls after any PDE5 inhibitor intervention of ≥4 weeks, excluding multiple interventions.
Burden of Pulmonary Hypertension in End-Stage Renal Disease Patients Receiving Maintenance Hemodialysis: Evaluation Factors and Treatment Strategies.
Cureus
September 2024
Community and Family Medicine, All India Institutes of Medical Sciences, Madurai, Madurai, IND.
Background Chronic kidney disease (CKD) is an emerging public health problem in India. Pulmonary hypertension (PH) is an overlooked cardiovascular complication of CKD. This study aimed to estimate the burden of PH among CKD patients undergoing hemodialysis in a selected tertiary care hospital.
View Article and Find Full Text PDFIncreased cGMP improves microvascular exercise training adaptations independent of endothelial nitric oxide synthase.
bioRxiv
September 2024
Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Article Synopsis
- * Researchers investigated the effects of the PDE-5a inhibitor sildenafil and found that it enhances the benefits of exercise by improving microcirculation and exercise capacity in diet-induced obese mice, but not in sedentary mice.
- * In lean mice with reduced endothelial nitric oxide synthase (eNOS), exercise training still improved endurance, indicating that while eNOS function is important, training alone can lead to significant benefits in microcirculation and exercise performance.
Nesfatin-1 regulates the phenotype transition of cavernous smooth muscle cells by activating PI3K/AKT/mTOR signaling pathway to improve diabetic erectile dysfunction.
PLoS One
September 2024
Urology Department of General Hospital, Ningxia Medical University, Ningxia, China.
Objective: This study aims to explore the impact of Nesfatin-1 on type 2 diabetic erectile dysfunction (T2DMED) and its underlying mechanism in regulating the phenotypic switching of corpus cavernosum smooth muscle cells (CCSMCs).
Methods: Twenty-four 4-week-old male C57 wild-type mice were randomly assigned to the control group, model group, and Nesfatin-1 treatment group. Monitoring included body weight, blood glucose levels, and penile cavernous pressure (ICP).
Nesfatin-1 regulates the phenotype transition of cavernous smooth muscle cells by activating PI3K/AKT/mTOR signaling pathway to improve diabetic erectile dysfunction.
Heliyon
July 2024
Urology Department of General Hospital, Ningxia Medical University, Ningxia 750000, China.
Objective: This study aims to explore the impact of Nesfatin-1 on type 2 diabetic erectile dysfunction (T2DMED) and its underlying mechanism in regulating the phenotypic switching of corpus cavernosum smooth muscle cells (CCSMCs).
Methods: Twenty-four 4-week-old male C57 wild-type mice were randomly assigned to the control group, model group, and Nesfatin-1 treatment group. Monitoring included body weight, blood glucose levels, and penile cavernous pressure (ICP).
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