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Objective: Skeletal muscle fat infiltration (myosteatosis) increases with age and is an emerging risk factor for dementia. We aimed to determine the association between myosteatosis and cognitive decline among middle-aged White and Black Americans.
Methods: Data were on men (n=1,080; 41.
Functional and Cognitive Impairment in Patients with Relapsing-Remitting Multiple Sclerosis: Cognitive Tests and Plasma Neurofilament Light Chain Levels.
Medicina (Kaunas)
January 2025
Department of Neurology and Neurosurgery, Riga East University Hospital, LV-1038 Riga, Latvia.
Multiple sclerosis (MS) is a chronic inflammatory, autoimmune, and neurodegenerative disease of the central nervous system. The disease can manifest and progress with both physical and cognitive symptoms, affecting the patient's daily activities. The aim of our study was to investigate the correlation between functional status, cognitive functions, and neurofilament light chain levels in plasma in MS patients.
View Article and Find Full Text PDFDoes exercise demonstrate a dose-dependent benefit with cognition in Parkinson's disease?
Parkinsonism Relat Disord
January 2025
Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address:
Background: Exercise confers motor benefits in Parkinson's disease (PD) and may even have disease modifying effects. While the impact of exercise on motor symptoms and quality of life is well-studied in PD, its relationship with cognitive performance warrants further attention.
Methods: In people with PD, self-reported exercise information was quantified using the Rapid Assessment of Physical Activity (RAPA).
Conventional MRI-Based Structural Disconnection and Morphometric Similarity Networks and Their Clinical Correlates in Multiple Sclerosis.
Neurology
February 2025
Department of Advanced Biomedical Sciences, University "Federico II," Naples, Italy.
Background And Objectives: Although multiple sclerosis (MS) can be conceptualized as a network disorder, brain network analyses typically require advanced MRI sequences not commonly acquired in clinical practice. Using conventional MRI, we assessed cross-sectional and longitudinal structural disconnection and morphometric similarity networks in people with MS (pwMS), along with their relationship with clinical disability.
Methods: In this longitudinal monocentric study, 3T structural MRI of pwMS and healthy controls (HC) was retrospectively analyzed.
"I know she's there" meanings of continuing bonds for bereaved Costa Rican men: a qualitative study.
Death Stud
January 2025
PhD Program in Medical and Pharmaceutical Sciences, Development and Quality of Life, Universidad de La Laguna, Santa Cruz de Tenerife, Spain.
This qualitative study addresses a gap in knowledge regarding men's experience of the grieving process. Our limited understanding of the topic hinders the development of targeted support services. The study analyzes the meanings of continuing bonds for bereaved men in Costa Rica.
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