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Metabolism of paeonol in rats. | LitMetric

Metabolism of paeonol in rats.

J Nat Prod

Department of Phytochemistry, Tohoku College of Pharmacy, 4-4-1, Komatsushima, Aoba-ku, Sendai, 981-8558, Japan.

Published: August 1999

As a part of our studies on the metabolism of active components from traditional Chinese medicines, paeonol was orally administered to rats. The urinary metabolites were analyzed by 3D HPLC, and their structures were determined to be 2, 4-dihydroxyacetophenone-5-O-sulfate (P1), resacetophenone-2-O-sulfate (P2), 2-hydroxy-4-methoxyacetophenone-5-O-sulfate (P3), paeonol-2-O-sulfate(P4), resacetophenone (P5), and unchanged paeonol, on the basis of their chemical and spectral data. Among these metabolites, P2-P4 and paeonol were detected in the plasma after the oral administration of paeonol. Furthermore, the bile of rats given paeonol orally was found to contain P3, suggesting the enterohepatic circulation of paeonol.

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http://dx.doi.org/10.1021/np980405lDOI Listing

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