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The paradoxical activity of BRAF inhibitors: potential use in wound healing.
Arch Dermatol Res
January 2025
Department of Translational & Clinical Research, School of Chemical and Life Sciences, Jamia Hamdard, Hamdard Nagar, New Delhi, 110062, India.
The area of wound healing presents a promising field of interest for clinicians as well as the scientific community. A major concern for physicians is the rising number of elderly people suffering from diabetes, leprosy, tuberculosis and the associated chronic wounds. While traditional therapies target basic wound care, innovative strategies that accelerate wound healing are needed.
View Article and Find Full Text PDFOptimal processing of tongue swab samples for detection by the Xpert MTB/RIF Ultra assay.
Microbiol Spectr
January 2025
Department of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
Tongue swabs represent a potential alternative to sputum as a sample type for detecting pulmonary tuberculosis (TB) with molecular diagnostic tests. The methods used to process tongue swabs for testing in the World Health Organization-recommended Xpert MTB/RIF Ultra (Xpert Ultra) assay vary greatly. Here, we aimed to identify the optimal tongue swab processing for Xpert Ultra testing.
View Article and Find Full Text PDFDecoding the Role of Antimicrobial Peptides in the Fight against .
ACS Infect Dis
January 2025
Infectious Diseases Division, CSIR─Indian Institute of Integrative Medicine, Jammu 180001, India.
Tuberculosis (TB), a leading infectious disease caused by the pathogen , poses a significant treatment challenge due to its unique characteristics and resistance to existing drugs. The conventional treatment regimens, which are lengthy and involve multiple drugs, often result in poor patient adherence and subsequent drug resistance, particularly with multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains. This highlights the urgent need for novel anti-TB therapies and new drug targets.
View Article and Find Full Text PDFBiological function of d-tryptophan: a bibliometric analysis and review.
Front Microbiol
January 2025
Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.
Background: d-Tryptophan is recognised for its unique physiological properties. In this study, we aimed to explore the dynamic trends and emerging topics in d-tryptophan research to offer fresh perspectives for future studies.
Methods: Employing bibliometric analysis, we examined the literature on d-tryptophan indexed in the Web of Science Core Collection from January 1987 to December 2023.
Epidemiological Analysis of Respiratory Diseases in Mexico From 2000 to 2020: Trends, Geographic Distribution, and Public Health Challenges.
Cureus
December 2024
Faculty of Biology, Autonomous University of Sinaloa, Culiacan, MEX.
Introduction: In Mexico, respiratory diseases such as tuberculosis (TB), acute respiratory infections (ARI), pertussis (Pt), and pneumonia-bronchopneumonia (Nemu) represent critical public health challenges that contribute to morbidity and mortality and are exacerbated by socioeconomic factors and the COVID-19 pandemic.
Objective: To evaluate the trends, seasonal patterns, and geographic distribution of major respiratory diseases in Mexico between 2000 and 2020.
Methodology: Data from the National Epidemiologic Surveillance System were analyzed using advanced statistical methods, including Kruskal-Wallis tests, Mann-Whitney analysis, and multivariate analysis, to identify temporal and regional variations.
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