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Imagine, Discover, Inspire: Proceedings of the 4th International Conference of the Trisomy 21 Research Society.
Neuromolecular Med
January 2025
Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA.
Down syndrome (DS) or trisomy 21 (T21) is present in a significant number of children and adults around the world and is associated with cognitive and medical challenges. Through research, the T21 Research Society (T21RS), established in 2014, unites a worldwide community dedicated to understanding the impact of T21 on biological systems and improving the quality of life of people with DS across the lifespan. T21RS hosts an international conference every two years to support collaboration, dissemination, and information sharing for this goal.
View Article and Find Full Text PDFAssessing the impact of different donor milk treatments on infant health and growth: a systematic review protocol.
BMJ Open
December 2024
Laboratory of Human Milk and Lactation Research, Department of Medical Biology, Medical University of Warsaw, Warsaw, Poland.
Introduction: Donor human milk (DHM) is the first alternative if mother's own milk is unavailable or contraindicated. Much DHM research has focused on its nutritional, immunological and biochemical composition in response to various maternal variables, standard human milk banking procedures and storage protocols. The current systematic review protocol, however, aims to systematically gather and analyse existing data pertaining to the impact of these aforementioned factors on the clinical, health-related and developmental outcomes observed in infants fed with DHM.
View Article and Find Full Text PDFExamination of the effect of treatment of severe early childhood caries and fluoride varnish applications on salivary oxidative stress biomarkers and antioxidants.
BMC Oral Health
December 2024
Cerrahpaşa Faculty of Medicine, Department of Medical Biochemistry, Istanbul University-Cerrahpaşa, Istanbul, Turkey.
Article Synopsis
- The study aimed to evaluate how dental treatments impact salivary oxidative stress markers in young children with severe early childhood caries (S-ECC) compared to those without caries.
- Salivary tests were performed at three time points (before treatment, after restorative care, and after fluoride varnish) on 40 children, and statistical analyses were used to assess differences in oxidative stress and antioxidant levels.
- Results showed that dental treatments reduced harmful oxidative stress markers and increased antioxidant levels in the saliva of children with S-ECC, highlighting the benefits of dental care in managing oral health and oxidative stress.
Design and development of spectrophotometric enzymatic cyanide assays.
Anal Bioanal Chem
December 2024
Institute of Microbiology of the Czech Academy of Sciences, CZ-142 00, Prague, Czech Republic.
Determination of free cyanide (fCN) is required for various industrial, environmental, food, and clinical samples. Enzymatic methods are not widely used in this field despite their selectivity and mild conditions. Therefore, we present here a proof of concept for new spectrophotometric enzymatic assays of fCN.
View Article and Find Full Text PDFPersistent and severe hypotension during radical transabdominal ovarian cancer surgery: A case report.
Medicine (Baltimore)
December 2024
Department of Anesthesiology, West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, Sichuan, China.
Rationale: In radical surgery for ovarian cancer (OC), hypotension that is difficult to correct is usually rare unless there is significant blood loss. We recently encountered a patient who developed persistent and severe hypotension during radical transabdominal OC surgery.
Patient Concerns: A patient was 52 years old with a history of hypertension and well-controlled preoperative blood pressure (BP).
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