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Schistosomes are parasitic flatworms that cycle between humans and freshwater snails, infecting more than 200 million humans. Many schistosome-endemic sites are invaded by non-native plants that snails cannot consume. Inedible plants could suppress snail growth, reproduction, and schistosome production by outcompeting edible resources.

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Detection of spp. DNA in gynaecological samples by quantitative real-time polymerase chain reaction (qPCR) is considered to be the reference diagnostic test for female genital schistosomiasis (FGS). However, qPCR needs expensive laboratory procedures and highly trained technicians.

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Purification and transcriptomic characterization of proliferative cells of selectively affected by irradiation.

Front Parasitol

March 2024

Departamento de Genética, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.

Flatworms depend on stem cells for continued tissue growth and renewal during their life cycles, making these cells valuable drug targets. While neoblasts are extensively characterized in the free-living planarian , and similar stem cells have been characterized in the trematode , their identification and characterization in cestodes is just emerging. Since stem cells are generally affected by irradiation, in this work we used this experimental approach to study the stem cells of the model cestode .

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Introduction: Schistosomiasis has for many years relied on a single drug, praziquantel (PZQ) for treatment of the disease. Immense efforts have been invested in the discovery of protein kinase (PK) inhibitors; however, given that the majority of PKs are still not targeted by an inhibitor with a useful level of selectivity, there is a compelling need to expand the chemical space available for synthesizing new, potent, and selective PK inhibitors. Small-molecule inhibitors targeting the ATP pocket of the catalytic domain of PKs have the potential to become drugs devoid of (major) side effects, particularly if they bind selectively.

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Background: Schistosomiasis is caused by infection with parasitic worms and affects more than 250 million people globally. The detection of schistosome derived circulating cathodic and anodic antigens (CCA and CAA) has proven highly valuable for detecting active infections, causing both intestinal and urinary schistosomiasis.

Aim: The combined detection of CCA and CAA was explored to improve accuracy in detecting infections.

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