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HoxBlinc lncRNA reprograms CTCF-independent TADs to drive leukemic transcription and HSC dysregulation in NUP98-rearranged leukemia.
J Clin Invest
January 2025
Division of Pediatric Hematology/Oncology, Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, United States of America.
Although nucleoporin 98 (NUP98) fusion oncogenes often drive aggressive pediatric leukemia by altering chromatin structure and expression of HOX genes, underlying mechanisms remain elusive. Here, we report that a Hoxb-associated lncRNA HoxBlinc was aberrantly activated in NUP98-PHF23 fusion-driven leukemias. HoxBlinc chromatin occupancies led to elevated MLL1 recruitment and aberrant homeotic topologically associated domains (TADs) that enhanced chromatin accessibilities and activated homeotic/hematopoietic oncogenes.
View Article and Find Full Text PDFInterplay between Skeletal Muscle Catabolism and Remodeling of Arteriovenous Fistula via YAP1 Signaling.
J Am Soc Nephrol
January 2025
Selzman Institute for Kidney Health, Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030.
Background: Arteriovenous (AV) fistulas are the preferred access for dialysis but have a high incidence of failure. This study aims to understand the crosstalk between skeletal muscle catabolism and AV fistula maturation failure.
Methods: Skeletal muscle metabolism and AV fistula maturation were evaluated in mice with chronic kidney disease (CKD).
Impact of High Intensity Interval Training on workload exercise progression in COPD with chronic respiratory failure: A pilot, feasibility, randomised trial.
Pulmonology
December 2025
Respiratory Rehabilitation Unit, Istituti Clinici Scientifici Maugeri IRCCS, Lumezzane, Italy.
Predicting maximum oxygen uptake using the six-minute walk distance in adults: What is the best curve fit estimation?
Pulmonology
December 2025
Department of Human Movement Sciences, Laboratory of Epidemiology and Human Movement - EPIMOV, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
The London chest activity of daily living revisited.
Pulmonology
December 2025
Faculty of Economics, Center for Health Studies and Research of the University of Coimbra: CEISUC, Coimbra, Portugal.
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