Unlabelled: The objective of the work was to assess whether in patients with IDDM without signs of diabetic retinopathy changes in the sensitivity function to contrast (CS) develop as compared with a group of healthy subjects matched for age but also as a result of the persistence of IDDM or the level of its long-term compensation investigated by means of glycated haemoglobin (HbA1c). CS was examined by the static method using a VCTS 6500 table from a distance of 208 and 420 cm which covered the spatial frequencies from 1.15 to 27.25 c/st. Moreover the authors assessed the best correctable central visual acuity on Snellen's optotypes, the ophthalmoscopic finding on the fundus with a colour photograph, fluorescein angiography and the HbA1c serum level. A group of 49 patients with IDDM was divided into two age groups: A(under 35 years), B (35 years and above). A marked decline of the CS function occurs in all spatial frequencies in both age groups. On comparison of the persistence of IDDM in group B no significant difference was found in CS, while in group A statistical significance was revealed in spatial frequencies 4 and 27.25 c/st. On comparison of the CS function in diabetics with a normal and pathological HbA1c level it was found that long-term hyperglycaemia has not a marked effect on visual functions.
Conclusion: The decline of CS in patients with IDDM without signs of diabetic retinopathy is influenced in particular by the patient's age, in junior patients also by the persistence of IDDM. Examination of the CS is a simple non-invasive method suitable for screening of early affections of the eyes in IDDM.
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J Nephrol
January 2025
Department of Diabetology, Endocrinology, Nephrology, University of Tuebingen, Tuebingen, Germany.
Background: The estimation of glomerular filtration rate (eGFR) is essential in the early detection of diabetic nephropathy. We herein compare the performance of common eGFR formulas against a gold standard measurement of GFR in patients with diabetes mellitus.
Methods: GFR was measured in 93 patients with diabetes mellitus using iohexol clearance as the reference standard.
Cells
January 2025
Unidad de Investigación Médica en Inmunología, de la UMAE Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico.
Type 1 diabetes (T1D) is a complex disease driven by the immune system attacking the insulin-producing beta cells in the pancreas. Understanding the role of different T cell subpopulations in the development and progression of T1D is crucial. By employing flow cytometry to compare the characteristics of T cells, we can pinpoint potential indicators of treatment response or therapeutic inefficacy.
View Article and Find Full Text PDFSci Diabetes Self Manag Care
January 2025
School of Nursing, Psychotherapy and Community Health, Dublin City University, Dublin, Ireland.
Purpose: The purpose of this study was to investigate adolescent perspectives of parent-adolescent communication, type 1 diabetes mellitus (T1DM)-specific family conflict, self-efficacy, and their relationship to adolescent self-management of T1DM.
Methods: A cross-sectional survey design was employed. Adolescents completed measures of parent-adolescent communication, T1DM-specific family conflict, self-efficacy, and self-management, which included activation and division of responsibility for management tasks.
Allergol Immunopathol (Madr)
January 2025
Prince Sattam bin Abdulaziz Research Chair for Epidemiology and Public Health, Department of Family and Community Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Background: Asthma is considered one of the most common and serious noncommunicable diseases, with high morbidity and mortality rates in both children and adults.
Objectives: To estimate the frequency and to determine the associated factors of self-reported asthma among children diagnosed with type 1 diabetes.
Methods: A cross-sectional study design was employed, and 175 subjects having type 1 diabetes for more than 1 year were included from the pediatrics endocrine clinic.
Pediatr Crit Care Med
January 2025
Division of Medical Critical Care, Department of Pediatrics, Boston Children's Hospital, Boston, MA.
Objectives: To assess factors associated with serum phosphorus (P) and hypophosphatemia in children with type 1 diabetes mellitus (T1DM) treated for diabetic ketoacidosis (DKA).
Design: Retrospective cohort.
Setting: Community-based PICU in a university-affiliated hospital.
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