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Effect of PCSK9 inhibitor on early neurological deterioration in acute ischemic stroke patients with a history of coronary heart disease: a study protocol for a randomized controlled trial in Dalian, China.
Trials
January 2025
Department of Neurology, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
Background: Early neurological deterioration (END) is a critical determinant influencing the short-term prognosis of acute ischemic stroke (AIS) patients and is associated with increased mortality rates among hospitalized individuals. AIS frequently coexists with coronary heart disease (CHD), complicating treatment and leading to more severe symptoms and worse outcomes. Shared risk factors between CHD and AIS, especially elevated low-density lipoprotein cholesterol (LDL-C), contribute to atherosclerosis and inflammation, which worsen brain tissue damage.
View Article and Find Full Text PDFCessation of thumb/finger sucking habit in children using electronic habit reminder versus palatal crib: a randomized clinical pilot study.
BMC Oral Health
January 2025
Paediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Cairo University, EL-Saraya Street, Cairo, Egypt.
Background: There are different intraoral appliances for cessation of thumb/finger sucking habit, but they have many disadvantages and to overcome it, extra oral appliances with colourful and attractive shape were developed. Electronic habit reminder in the form of wristwatch with alarming sound was assessed in cessation of thumb/finger sucking habit in children versus palatal crib after 6 and 9 months.
Methods: This study is a randomized clinical pilot study, with allocation ratio 1:1 parallel group.
Access Program for Unapproved and Off-Label Drug Use in Pediatric BRAF V600E-Mutated Brain Tumors in Japan.
Pediatr Blood Cancer
January 2025
Department of Pediatrics. Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Programs allowing access to investigational drugs and off-label drug use for serious diseases have often been applied to pediatric cancers. A clinical study conducted under the Japanese "Patient-Proposed Healthcare Services" evaluated the efficacy and safety of dabrafenib plus trametinib in children with BRAF V600 mutant glioma (jRCTs071210071). This study successfully provided unapproved and off-label medications to four enrolled patients, two with low-grade glioma and two with high-grade glioma (median age: 10.
View Article and Find Full Text PDFEfficacy of acceptance and commitment therapy on psychological rehabilitation in cancer patients treated with proton and heavy ion therapy: a non-randomized controlled trial.
Support Care Cancer
January 2025
Department of Nursing, Shanghai Proton and Heavy Ion Center, Shanghai Key Laboratory of Radiation Oncology (20dz2261000), Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Fudan University Cancer Hospital, Shanghai, China.
Objective: To develop an appropriate intervention utilizing acceptance and commitment therapy (ACT) tailored specifically for cancer patients undergoing radiotherapy, and to investigate its impact on hope, psychological resilience, psychological flexibility, and psychological distress among cancer patients receiving proton and heavy ion therapy.
Methods: Eighty participants were allocated into an intervention group (n = 40) or a control group (n = 40) based on their admission time. The control and intervention groups underwent a 3-week health education program, with the intervention group additionally participating in a 3-week, 6-session acceptance and commitment therapy (ACT) group psychological intervention.
Effects of Tai Chi Chuan on physical function and health in breast cancer patients.
Support Care Cancer
January 2025
S' Clinic, Guangzhou, 510000, China.
Purpose: This study aims to explore the effects of Tai Chi Chuan (TCC) on physical function, hematological metabolic biomarkers, sleep quality, and mental health in breast cancer patients.
Methods: This was a prospective clinical trial that involved 37 breast cancer patients who had completed surgery treatment. Participants' motor function, hematological examination, and self-rated questionnaire were assessed at the baseline and after the intervention.
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