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Nevirapine-induced Stevens-Johnson syndrome in children living with HIV in South Africa.
South Afr J HIV Med
February 2021
HIV Outpatient Department, Zithulele Hospital, Mqanduli, South Africa.
Background: Although adverse drug reactions resulting from the use of nevirapine (NVP) are well described in adults (estimated frequency of 6% - 10%), it has previously been considered less common in children (0.3% - 1.4%).
View Article and Find Full Text PDFFatal Nevirapine-Induced Toxic Epidermal Necrolysis in a HIV Infected Patient.
J Clin Diagn Res
March 2016
Professor, Department of Clinical & Experimental Pharmacology, Calcutta School of Tropical Medicine, Kolkata, India .
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are the most Severe Cutaneous Adverse Reactions (SCARs) which mainly caused by exposure to drugs and having significant morbidity and mortality. TEN represents an immunologic reaction to a foreign antigen and is most often caused by drugs. Nevirapine (NVP), a non-nucleoside reverse transcriptase inhibitor (NNRTI) is an important component of Highly Active Antiretroviral Therapy (HAART).
View Article and Find Full Text PDFHLA-allelotype associations with nevirapine-induced hypersensitivity reactions and hepatotoxicity: a systematic review of the literature and meta-analysis.
Pharmacogenet Genomics
April 2015
aWolfson Centre for Personalised Medicine, Department of Molecular and Clinical Pharmacology bDepartment of Biostatistics, University of Liverpool, Liverpool, UK.
Objective: Various studies have investigated associations between immunogenetic (HLA-allelotypes) factors and the risk of nevirapine-induced hypersensitivity reactions. However, results from individual studies have been inconsistent. To evaluate the association between HLA alleles and nevirapine hypersensitivity, a systematic review and meta-analysis was carried out.
View Article and Find Full Text PDFOral lesions associated with Nevirapine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: A report of 10 cases.
J Oral Maxillofac Pathol
September 2013
Department of Oral Pathology, Sibar Institute of Dental Sciences, Takkellapadu, Guntur, Andhra Pradesh, India.
Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are closely related severe, acute mucocutaneous reactions usually caused by drugs. They are acute life-threatening conditions and cause widespread necrosis of the epithelium. There is persistence of a high risk of SJS or TEN in relation to human immunodeficiency virus (HIV) infection associated with exposure to nevirapine (NVP).
View Article and Find Full Text PDFChanging incidence of nevirapine-induced cutaneous drug reactions: After revised guideline Nov 2011.
Indian J Sex Transm Dis AIDS
July 2013
Department of Skin and VD, Head of ART Centre, B. J. Medical College, Ahmedabad, India.
Aims And Objectives: To study the change in the incidence and pattern of nevirapine (NVP)-induced adverse cutaneous reactions (ADR) after commencement of revised National AIDS Control Organisation (NACO) guidelines for initiation of antiretroviral therapy (ART) since Nov 2011.
Materials And Methods: The study was conducted on patients who developed cutaneous reactions after starting NVP based regimen. According to the revised NACO ART initiation guidelines Nov 2011, ART should be started if CD4 count is < 350 cells/mm(3) in stages 1, and 2 and irrespective of CD4 count in stages 3, and 4.
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