Objective: To report our results in a selected series of patients who had two separate hepatocellular carcinomas that were not suitable for treatment by resection alone or percutaneous injection of ethanol alone, whom we treated by a combination of the two.
Design: Open study.
Setting: Teaching hospital, Italy.
Subjects: 11 patients with Child's grade A or B cirrhosis who had two hepatocellular carcinomas in distant segments of the liver.
Interventions: Percutaneous injection of ethanol into the smaller of the two nodules before, during, or after resection.
Main Outcome Measures: Morbidity, mortality, and recurrence.
Results: No patient died and there was one postoperative complication (atelectasis). During a median follow-up period of 24 months (range 8-48) two patients have developed recurrences (at 10 and 18 months).
Conclusion: Although we have studied only a few patients for a relatively short time this double approach may be an important treatment option for suitable patients with two hepatocellular carcinomas.
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