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Infective endocarditis commonly presents with fever, malaise, fatigue, and chest pain. However, this case report details an atypical presentation of infective endocarditis when a 63-year-old male patient was referred by his general practitioner to the emergency department with shortness of breath and substantial weight loss to investigate his symptomatic anemia. His initial assessments revealed severe iron deficiency anemia without any gastrointestinal or any other source of bleeding.

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Amoxicillin Blood Concentration in High-Dose Intravenous Discontinuous Amoxicillin: Look Beyond Numbers. Max-Amox Study.

Clin Ther

December 2024

Department of Infectious Diseases, CHU Clermont-Ferrand, Clermont-Ferrand, France. Electronic address:

Purpose: High doses of amoxicillin are recommended to treat severe infections such as endocarditis. Amoxicillin causes dose-dependent toxicities, in particular crystal nephropathy. Toxicity could be avoided by monitoring of amoxicillin trough plasma concentrations (ATPC).

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Mortality Profile of Deaths Related to Infective Endocarditis in Brazil and Regions: A Population-Based Analysis of Death Records.

Trop Med Infect Dis

November 2024

Department of Specialized Medicine-Cardiology Discipline, School of Medicine and Surgery, Federal University of the State of Rio de Janeiro, Rua Silva Ramos, 32, Tijuca, Rio de Janeiro 20270-330, Brazil.

Background: Studies of infective endocarditis (IE) are generally limited to institutions, underlining the need for more comprehensive epidemiological research.

Objective: The aim of this study was to determine the mortality profile of IE-related deaths and related causes in Brazil at the national level and across regions.

Method: We conducted a population-based study using data from the country's mortality information system for the period 2000 to 2019.

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Role of Multimodal Imaging in Clinical Practice for the Diagnosis of Infective Endocarditis: A Case Series.

Infect Dis Rep

December 2024

Infectious Diseases Clinic, Santa Maria della Misericordia Hospital, Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy.

Background: The 2023 European Society of Cardiology (ESC) guidelines for the management of infective endocarditis (IE) highlighted the essential role of multimodal imaging in the diagnostic algorithm of IE and its complications.

Methods: We hereby report a case series of IE in which the diagnosis was confirmed or excluded by the use of multimodal imaging during the period between January 2024 and July 2024 at the Infectious Diseases Clinic, Perugia Hospital, Italy.

Results: Six patients were retrospectively included.

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Background: Utilization of transvenous lead extraction/removal (TLE) for the management of cardiac implantable electronic device (CIED)-associated infective endocarditis (IE) remains low.

Objective: To examine the impact of hospital TLE procedural volume on TLE utilization and outcomes for patients with CIED-associated IE.

Methods: Using the Nationwide Readmissions Database, we evaluated 21,545 admissions for patients (mean age 70, 39% female) with CIEDs hospitalized with IE at TLE centres.

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