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Design and synthesis of diaminopyrrolidinone inhibitors of human osteoclast cathepsin K. | LitMetric
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Design and synthesis of diaminopyrrolidinone inhibitors of human osteoclast cathepsin K.

K J Duffy L H Ridgers R L DesJarlais T A Tomaszek M J Bossard S K Thompson R M Keenan D F Veber

Bioorg Med Chem Lett

Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals, Collegeville, PA 19246, USA.

Published: July 1999

The structure-based design and synthesis of lactam-constrained azapeptide inhibitors of human cathepsin K are described. Enhanced stability to proteolytic cleavage over acyclic analogues is discussed.

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 Source
http://dx.doi.org/10.1016/s0960-894x(99)00322-4DOI Listing

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