AI Article Synopsis
- Two nitrosation products of hexamethylenetetramine were synthesized, specifically 1,3,5-trinitrosohexahydro-1,3,5-triazine and 3,7-dinitroso-1,3,5,7-tetrazabicyclo[3.3.1]nonane.
- Both compounds were shown to produce nitric oxide in vitro at different rates when tested at body temperature and neutral pH.
- In rats, both compounds reduced thrombus formation in blood vessels, while compound 2 did not affect blood pressure in hypertensive rats.
Article Abstract
Two nitrosation products of hexamethylenetetramine, namely 1,3,5-trinitrosohexahydro-1,3,5-triazine (1) and 3,7-dinitroso- 1,3,5,7-tetrazabicyclo[3.3.1]nonane (2), were synthesized. It is shown that both compounds in vitro at 37 degrees C (1 h, pH 7.4) form nitric oxide at a rate of 3.1% (1) or 1.3% (2), respectively. In rats (60 mg/kg p.o.) both compound inhibit thrombus formation in arterioles (1: 20%; 2: 16%) and venules (1: 18%; 2: 9%). Compound 2 does not influence the blood pressure in spontaneously hypertensive rats.
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| http://dx.doi.org/10.1002/(sici)1521-4184(19997)332:7<255::aid-ardp255>3.0.co;2-r | DOI Listing |
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