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Dermatophytes: Update on Clinical Epidemiology and Treatment.
Mycopathologia
November 2024
Clinic for Infectious and Tropical Diseases, University Clinical Center of Serbia, Belgrade, Serbia.
Dermatophytes represent the largest and most common group of fungal infections, impacting 25% of the global population. Among them, Trichophyton rubrum has emerged as the predominant species, responsible for a range of conditions such as tinea corporis, tinea pedis, onychomycosis, tinea cruris, and tinea manuum. Although dermatophyte incidence varies geographically, there is a noticeable rise in cases caused by T.
View Article and Find Full Text PDFDetection of terbinafine-resistant Trichophyton indotineae isolates within the Trichophyton mentagrophytes species complex isolated from patients in Hue City, Vietnam: A comprehensive analysis.
Med Mycol
August 2024
Institute of Biomedicine, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen Street, 49000 Hue City, Vietnam.
Article Synopsis
- The Trichophyton mentagrophytes complex includes dermatophyte fungi that cause skin infections, with a rising concern of drug resistance, especially in Trichophyton indotineae, which shows terbinafine resistance.
- A study in Hue City, Vietnam analyzed these fungi's characteristics and antifungal susceptibilities, revealing that 24% of superficial mycoses were linked to this complex, predominantly identifying T. interdigitale genotype II.
- While the fungi were generally sensitive to itraconazole and voriconazole, about 50% of T. indotineae isolates were resistant to terbinafine due to a specific mutation, highlighting the urgent need for better strategies to combat drug resistance in dermatology.
The mitochondrial protein Bcs1A regulates antifungal drug tolerance by affecting efflux pump expression in the filamentous pathogenic fungus .
Microbiol Spectr
October 2024
Anhui Key Laboratory of Infection and Immunity, School of Basic Medicine, Bengbu Medical University, Bengbu, China.
is the predominant pathogen responsible for aspergillosis infections, with emerging drug-resistant strains complicating treatment strategies. The role of mitochondrial functionality in fungal resistance to antifungal agents is well-documented yet not fully understood. In this study, the mitochondrial protein Bcs1A, a homolog of yeast Bcs1, was found to regulate colony growth, ion homeostasis, and the response to antifungal drugs in .
View Article and Find Full Text PDFDermatophytosis Caused by Trichophyton indotineae (Trichophyton mentagrophytes ITS Genotype VIII) in Sri Lanka.
Am J Trop Med Hyg
September 2024
Laboport Medical Laboratories, Leipzig-Mölbis, Germany.
Over the past few years, a recalcitrant dermatophytosis has been observed on the Indian subcontinent, including Sri Lanka, which has caused a major public health issue in the region. An emerging species, Trichophyton indotineae, first described as Trichophyton mentagrophytes ITS genotype VIII, is thought to be responsible for this fast-spreading, mostly terbinafine-resistant dermatophytosis. Recalcitrant dermatophytosis is a challenge to dermatologists, and knowing the causative species and antifungal sensitivity in the earlier stage of management would be invaluable.
View Article and Find Full Text PDFDual quantitative PCR assays for the rapid detection of Trichophyton indotineae from clinical samples.
Med Mycol
July 2024
Laboratoire de parasitologie-mycologie, AP-HP, Hôpital Saint-Louis, F-75010 Paris, France.
Article Synopsis
- Trichophyton indotineae is a new strain related to hairless skin infections and often resists the antifungal drug terbinafine, making timely diagnosis crucial for effective treatment.
- Researchers created a dual quantitative PCR (qPCR) test that can quickly and accurately identify T. indotineae directly from clinical samples, bypassing the slower culture methods.
- The test shows high specificity (100%) for T. indotineae, ensuring that patients can receive early and appropriate treatment based on quick detection from skin scrapings.
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