Purpose: To study refraction variations during the day in eyes with intrastromal corneal ring segments (ICRS) to correct low myopia.
Setting: Monticelli Clinic, Marseille, France.
Methods: Thirteen eyes with ICRS were included in the study; the ICRS was explanted from 3 eyes because of undercorrection. The minimum follow-up in all eyes was 1 year. The same observer measured refraction and keratometry at 9:00 AM, 1:00 PM, and 7:00 PM with the same autokeratorefractometer. To validate the analysis method, these eyes were compared with a group of emmetropic control eyes that had not had surgery and with a group of eyes that had photorefractive keratectomy for a similar degree of myopia. All measurements were done under the same conditions.
Results: After 1 year, the ICRS eyes showed a tendency toward an evening myopic shift. This was confirmed by the objective keratometry study, which showed variations closely correlated with the myopia observed. These phenomena were not observed in the other groups.
Conclusion: The ICRS had satisfactory predictability in eyes with up to -3.50 diopters of myopia. However, the evening myopic shift appeared similar to that observed after radial keratotomy.
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http://dx.doi.org/10.1016/s0886-3350(99)00129-7 | DOI Listing |
Acad Radiol
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Department of Radiology, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai 200031, China (Q.X.). Electronic address:
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Center for Orphan Drug Research, Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, United States. Electronic address:
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University of Ljubljana, Faculty of Pharmacy, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia. Electronic address:
Dry eye disease is a multifactorial condition characterized by a loss of homeostasis of the tear film. Among the various treatment approaches, the application of ophthalmic oil-in-water nanoemulsions with incorporated anti-inflammatory drugs represents one of the most advanced approaches. However, the liquid nature of nanoemulsions limits their retention time at the ocular surface.
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Centre for Ocular Regeneration (CORE), L V Prasad Eye Institute, Hyderabad, Telangana, India; Prof. Krothapalli Ravindranath Ophthalmic Research Biorepository, LV Prasad Eye Institute, Hyderabad, Telangana, India.
Extracellular vesicles (EVs), defined as membrane-bound vesicles released from all cells, are being explored for their diagnostic and therapeutic role in dry eye disease (DED). We systematically shortlisted 32 articles on the role of EVs in diagnosing and treating DED. The systematic review covers the progress in the last 2 decades about the classification and isolation of EVs and their role in DED.
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