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Causal associations between insulin and Lp(a) levels in Caucasian population: a Mendelian randomization study.
Cardiovasc Diabetol
August 2024
Department of Preventive Cardiology and Lipidology, Medical University of Lodz, Lodz, Poland.
Background: Numerous observational studies have demonstrated that circulating lipoprotein(a) [Lp(a)] might be inversely related to the risk of type 2 diabetes (T2D). However, recent Mendelian randomization (MR) studies do not consistently support this association. The results of in vitro research suggest that high insulin concentrations can suppress Lp(a) levels by affecting apolipoprotein(a) [apo(a)] synthesis.
View Article and Find Full Text PDFInsulin resistance biomarkers in small-for-gestational-age infants born to mothers with gestational diabetes mellitus.
J Matern Fetal Neonatal Med
December 2022
Department of Neonatology, Guangzhou Women and Children's Medical Centre, Guangzhou Medical University, Guangzhou, PR China.
Objective: Early alterations in glucose homeostasis increase the risk of developing insulin resistance (IR) and obesity later in life. The study aimed to ascertain the peripheral blood levels of hormones that controlling glucose homeostasis and inflammatory factors that are correlated with IR and fetal outcomes in small-for-gestational-age (SGA) infants born to mothers with gestational diabetes mellitus (GDM).
Methods: This cohort study included a total of 90 SGA infants born to mothers with GDM ( = 37) and without GDM ( = 53).
HDL as a Target for Glycemic Control.
Curr Drug Targets
April 2018
NHMRC Clinical Trials Centre, Sydney Medical School, University of Sydney, NSW, Australia.
HDL has long been known for its role in reverse cholesterol transport, thought in part to explain the well-recognized links between low levels of HDL-C and cardiovascular disease. The past decade has seen increasing evidence from epidemiological, basic science and early human intervention studies that HDL biology is more complex and may influence the onset and progression of type 2 diabetes. Research has identified multiple potential pathways by which higher HDL particle concentrations or functional improvements may ameliorate the development and progression of the disease.
View Article and Find Full Text PDFLipoprotein(a): from molecules to therapeutics.
Am J Ther
August 2010
Endocrine and Metabolic Diseases Research Center, University of Zulia, School of Medicine, Maracaibo, Venezuela.
Lipoprotein (a) [Lp(a)] was discovered by Kare Berg in 1963 from the study of low-density lipoprotein genetic variants. Lp(a) contains a unique protein, apolipoprotein(a), which is linked to the Apo B-100 through a disulfide bond that gives it a great structural homology with plasminogen, and confers it atherogenic and atherothrombotic properties. Interest in Lp(a) has increased because an important association between high plasma levels of Lp(a) and coronary artery disease and cerebral vascular disorders has been demonstrated.
View Article and Find Full Text PDFDecrease of Lp(a) during weight reduction in obese children is modified by the apo(a) kringle-IV copy number variation.
Int J Obes (Lond)
October 2009
Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Schöpfstrasse, Innsbruck, Austria.
Background: Lipoprotein(a) [Lp(a)] is considered an independent risk factor for cardiovascular disease. Its concentration is mainly determined by the kringle-IV repeat copy number variation (CNV) at the apolipoprotein(a) [apo(a)] locus.
Objective: We aimed to investigate the immediate effect of weight reduction on plasma Lp(a) levels and its dependency on the apo(a) CNV in obese children.
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