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A multi-tissue longitudinal proteomics study to evaluate the suitability of post-mortem samples for pathophysiological research.
Commun Biol
January 2025
Cardio-Thoracic Translational Medicine (CTTM) Lab, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Recent developments in mass spectrometry-based proteomics have established it as a robust tool for system-wide analyses essential for pathophysiological research. While post-mortem samples are a critical source for these studies, our understanding of how body decomposition influences the proteome remains limited. Here, we have revisited published data and conducted a clinically relevant time-course experiment in mice, revealing organ-specific proteome regulation after death, with only a fraction of these changes linked to protein autolysis.
View Article and Find Full Text PDFMice develop obesity and lose myocardial metabolic flexibility months after exertional heat stroke.
Commun Biol
January 2025
Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, FL, USA.
As global temperatures rise, heat-related chronic health disorders are predicted to become more prevalent. We tested whether a single exposure to acute heat illness, using a preclinical mouse model of exertional heat stroke (EHS), can induce late-emerging health disorders that progress into chronic disease. Following EHS, mice were followed for 3 months; after two weeks of recovery, half were placed on a Western diet to determine if previous EHS exposure amplifies the negative consequences of an atherogenic diet.
View Article and Find Full Text PDFPost-myocardial infarction ventricular septal defects: incidence and treatment trends during and after the COVID-19 pandemic.
Sci Rep
January 2025
Department of Cardiovascular Surgery, GVM Care & Research, Anthea Hospital, Bari, Italy.
Ventricular septal defect (VSD) is a serious complication of myocardial infarction (MI), with its global incidence significantly reduced in recent years due to advances in coronary reperfusion techniques. However, during the COVID-19 pandemic, there was an unexpected rise in the incidence of post-MI VSD, likely driven by delays in seeking treatment. This study retrospectively analyzed 10 cases of post-MI VSD treated at our hospitals from March 2018 to August 2023, comparing incidence rates across pre-pandemic, pandemic, and post-pandemic periods.
View Article and Find Full Text PDFTakotsubo Cardiomyopathy in Epilepsy: A Systematic insight into the Existing Literature from 2000-2023.
Pak J Med Sci
December 2024
Professor Asif Bashir, Punjab Institute of Neurosciences, Lahore, Punjab, Pakistan.
Background & Objective: Takotsubo cardiomyopathy (TCM), manifests as left ventricular dysfunction triggered by physical or emotional stress. It leads to higher morbidity in epileptic patients and can progress to complications. To find out the correlation between Takotsubo cardiomyopathy and epilepsy and to investigate pathophysiology and associated types of epilepsy.
View Article and Find Full Text PDFTrends in Sudden Cardiac Death Among Adults Aged 25 to 44 Years in the United States: An Analysis of 2 Large US Databases.
J Am Heart Assoc
January 2025
Division of Cardiovascular Medicine Brigham and Women's Hospital, Harvard Medical School Boston MA.
Background: Sudden cardiac death (SCD) in early adults aged 25 to 44 years represents an important and unexpected cause of death. We assessed trends in SCD-related mortality in the United States from 1999 to 2020 among early adults to determine differences by sex, ethnoracial groups, urbanization, and census region.
Methods And Results: Mortality data were retrieved from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) data set from 1999 to 2020.
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