[The experimental pathology and clinical treatment of microwave tissue coagulation for ocular superficial lesions].

Objective: To investigate the therapeutic effect of a new therapy, microwave tissue coagulation (MTC), for treatment of ocular diseases.

Methods: HSE-5M Mircotaze (manufactured by HEIWA Electronic Industrial Co. Osaka, Japan) was used for the treatment of sixty-four cases with ocular superficial lesions. Animal experiment was performed with this technique before application in patients. Twelve rabbit monocular eyeballs were coagulated just posterior to the corneoscleral limbus in order to find a dose which is effective and safe for the human eye ball. The models of microwave coagulative lesions were made in the contralateral eyes of the twelve rabbit eyeballs.

Results: The coagulation-induced "ulcers" were exfoliated gradually and healed finally from three to seven days. Histopathology of the coagulative areas showed coagulative necrosis with infiltration of lymphocytes and plasma cells. The results of sixty-four cases treated with MTC technique show that the damaging effect of coagulation on tissues is very mild, so that it heals very soon and the clinical process is consistent with the experimental pathological process.

Conclusions: If the dosage of the technique is controlled in the range of safety and effectiveness, the MTC therapy is effective for the treatment of superficial ocular disease. The clinical and pathological examinations demonstrate that the therapy does not damage the ocular structure.