Effects of acute intraperitoneal administration of tetrazepam on blood glucose level and serum lipids in hyperlipidemic albino rats.

In rats rendered hyperlipidemic by the i.p. injection of Triton WR-1339, the i.p. administration of tetrazepam, a benzodiazepine (BZD) used mainly as a central myorelaxant, evoked significant reductions of serum lipids and blood glucose level. The dose-response curve was bell-shaped for serum lipids changes, whereas no clear dose-response relationship for blood glucose level modifications could be established. Tetrazepam was less active on serum lipids than other BZDs as diazepam or midazolam.