Purpose: To evaluate ankle areflexia in Holmes-Adie syndrome (HAS).
Patients And Methods: Hoffmann (H) and Tendon (T) soleus reflexes, tonic vibration reflex (TVR), and polysynaptic extension reflex of soleus muscle (PERS) were evaluated in eight patients with idiopathic HAS. Motor (MNCV) and sensory (SNCV) nerve conduction velocities, compound motor-action potential (CMAP), and sensory action potential (SAP) were also determined in upper and lower limbs.
Results: Soleus T reflex was obtained in one out of eight patients, and H-reflex was found in none of the patients. TVR was recorded in four out of eight patients, and PERS in all of the patients. MNCV, SNCV, CMAP and SAP showed normal values in all patients. In six out of the eight patients a late response following the tibial nerve stimulation showed constant latency, amplitude and morphology, with no recovery cycle or vibration inhibition.
Conclusion: In this study, the neurophysiological spinal reflex circuitry evaluations support the view that HAS ankles areflexia is due to a selective impairement of monosynaptic connections of Ia afferents. A normal nuclear excitability is suggested by polysynaptic activation of the soleus motor nucleus.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/S0987-7053(99)80061-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Areflexia in Holmes-Adie syndrome: A sign in search of its pathophysiology.
Neurophysiol Clin
December 2017
Division of Neurology, National Institute of Neurology and Neurosurgery, 14269 Mexico City, Mexico.
Asymptomatic Severe Vagal and Sympathetic Cardiac Denervation in Holmes-Adie's Syndrome.
Case Rep Neurol Med
March 2017
Department of Internal Medicine, University Hospital, Autonomous University of Nuevo León, Monterrey, NL, Mexico.
A 40-year-old woman was found to have bilateral Adie's pupils and generalized muscle stretch areflexia. She did not have orthostatic hypotension but, in an ECG strip in the office, she appeared to have an almost fixed heart rate. We thus studied the heart rate variability (HRV) and the systolic blood pressure variability (SBPV) in supine and standing position and also during rhythmic breathing.
View Article and Find Full Text PDFRoss Syndrome: A Case Report and Review of Cases from India.
Indian J Dermatol
June 2016
Department of Neurology, Christian Medical College, Vellore, Tamil Nadu, India.
Ross syndrome is a rare dysautonomia characterized by a clinical complex of segmental anhidrosis or hypohidrosis, areflexia, and tonic pupils. A very few cases (≃50) have been reported in literature since its original description in 1958. Here, we report the case of a middle-aged homemaker from Odisha, India, who presented with complaints of segmental hypohidrosis for the past 7 years.
View Article and Find Full Text PDFProgression of cardiovascular autonomic dysfunction in Holmes-Adie syndrome.
J Neurol Neurosurg Psychiatry
September 2011
Autonomic Unit, National Hospital for Neurology and Neurosurgery, Queen Square & Institute of Neurology, University College London, London, UK.
The Holmes-Adie Syndrome (HAS) is a disorder of unknown aetiology comprising unilateral or bilateral tonic pupils with near light dissociation and tendon areflexia. Although considered to be benign, troublesome symptoms may result from autonomic disturbances, affecting vasomotor, sudomotor and respiratory function. It is unclear if the autonomic manifestations of the disease remain stable or progress, as longitudinal studies with detailed autonomic assessments have not been described.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!