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Exploring the management of recurrent angioedema caused by different mechanisms.
Curr Opin Allergy Clin Immunol
February 2025
Department of Medicine and Medical Specialties, A. Cardarelli Hospital, Naples, Italy.
Purpose Of Review: We aim to explore the most recent insights into the pathogenesis of recurrent angioedema caused by different mechanisms and then focus on the management and treatment approaches available.
Recent Findings: The recently developed DANCE consensus classification identifies five types of angioedema: mast cell-mediated (AE-MC), bradykinin-mediated, because of intrinsic vascular endothelium dysfunction (AE-VE), drug-induced (AE-DI), and due to unknown mechanisms (AE-UNK). These subtypes require different management with treatment choices targeting the main pathogenetic pathways involved in each form.
Dancing with disorder: chorea - an unusual and neglected manifestation of antiphospholipid syndrome.
Lupus Sci Med
October 2024
Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
Article Synopsis
- Chorea, a rare neurological issue related to antiphospholipid syndrome (APS), involves involuntary movements, with unclear clinical features; this study examines the evidence of chorea associated with antiphospholipid antibodies (aPL).
- The research included 180 patients, mostly women around 22.8 years old, revealing that most had chorea as their first symptom and often experienced it as a single episode, with notable laboratory findings including high positivity rates for various aPL tests.
- Treatment varied widely but led to improvement in 95.5% of patients, highlighting that chorea, while significant, is often not recognized as a symptom of APS.
Sepsis, a multifaceted syndrome driven by an imbalanced host response to infection, remains a significant medical challenge. At its core lies the pivotal role of glycolysis, orchestrating immune responses especially in severe sepsis. The intertwined dynamics between glycolysis, sepsis, and immunity, however, have gaps in knowledge with several Crucial genes still shrouded in ambiguity.
View Article and Find Full Text PDFImmunological crossroads: The intriguing dance between hepatitis C and autoimmune hepatitis.
World J Hepatol
June 2024
Department of Acute Medicine and Gastroenterology, University of South Wales, Cardiff CF37 1DL, United Kingdom.
Delving into the immunological crossroads of liver diseases, this editorial explores the dynamic interplay between hepatitis C virus (HCV) and autoimmune hepatitis (AIH). While HCV primarily manifests as a viral infection impacting the liver, previous studies unveil a captivating connection between HCV and the emergence of AIH. The dance of the immune system in response to HCV appears to set the stage for an intriguing phenomenon-an aberrant autoimmune response leading to the onset of AIH.
View Article and Find Full Text PDFDefinition, acronyms, nomenclature, and classification of angioedema (DANCE): AAAAI, ACAAI, ACARE, and APAAACI DANCE consensus.
J Allergy Clin Immunol
August 2024
Angioedema Center of Reference and Excellence (ACARE), Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine, and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany.
Article Synopsis
- Angioedema (AE) is a condition characterized by localized swelling in the skin or mucous membranes and can be hereditary or acquired, making its classification complex due to various underlying mechanisms and taxonomies.
- The DANCE initiative, involving 91 experts from 35 countries, aimed to create a unified consensus on the definition, acronyms, and classification of AE through an extensive online discussion and voting process over 16 months.
- The resulting DANCE classification introduces five types of AE, standardizes terminology, and is designed to enhance research and patient care while complementing existing clinical guidelines without replacing them.
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