The aim of this study was to investigate clinical features of an antigen-induced arthritis model in the rabbit temporomandibular joint (TMJ) and compare them to those in knee joint (KJ) arthritis. Eighteen adult male New Zealand White rabbits were divided into a TMJ arthritis group and a KJ arthritis group. Monoarthritis was induced unilaterally with ovalbumin and clinical observations, including joint swelling, skin surface temperature (SST) over the joints, and the withdrawal reflex threshold (WRT) to noxious pressure, were performed over a 3 week period. The joints were then evaluated histologically. The WRT was decreased during the 3 weeks after induction of TMJ arthritis, together with mild but significant joint swelling. The arthritic KJ also showed significant swelling and reduced WRT during the 3 week period. A significant increase of SST over the arthritic TMJ was present during the first week, while changes in SST over the KJ were inconsistent. The histological evaluation showed chronic arthritic features in all arthritic joints of both groups and no difference in the severity of arthritis was found between the TMJ and the KJ.
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http://dx.doi.org/10.1111/j.1600-0714.1999.tb02037.x | DOI Listing |
ACS Pharmacol Transl Sci
December 2024
Department of Pharmacy, The Second Affiliated Hospital of Wannan Medical College, Wuhu 241000, China.
Triglyceride (TG) and its derivatives tend to be decreased in rheumatoid arthritis (RA) patients' blood when inflammation progresses. Aside from the role as a lipid buffer, white adipose tissue (WAT) contributes to this abnormality via adipokines, which regulate many metabolic signals. This work investigated adipokine-caused hepatic changes and their involvement in RA-related hypolipemia.
View Article and Find Full Text PDFJ Ethnopharmacol
February 2025
Departament of Pharmaceutical Products, Faculty of Pharmacy, Universidade Federal de Minas Gerais, campus Pampulha, Avenida Antônio Carlos 6627, 31.270-901, Belo Horizonte, MG, Brazil. Electronic address:
Ethnopharmacological Relevance: Echinodorus macrophyllus is a medicinal plant traditionally used in Brazil to treat rheumatic diseases. It is listed as a priority species for the development of herbal preparations for the Brazilian Unified Health System (SUS). Previous studies have demonstrated the anti-inflammatory and antiedematogenic properties of extracts and fractions from this species, but these preparations were neither standardized nor optimized for anti-arthritis effects.
View Article and Find Full Text PDFJ Biomed Res
November 2024
Department of Rheumatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Adiponectin receptor 1 ( ) deficiency has been shown to inhibit Th17 cell differentiation and reduce joint inflammation and bone erosion in antigen-induced arthritis (AIA) mice. Additional emerging evidence indicates that Th17 cells may differentiate into pathogenic (pTh17) and non-pathogenic (npTh17) cells, with the pTh17 cells playing a crucial role in numerous autoimmune and inflammatory conditions. In the current study, we found that deficiency inhibited pTh17 differentiation and that the deletion of in pTh17 cells reduced the mitochondrial function.
View Article and Find Full Text PDFInt J Pharm
December 2024
National Institute of Pharmaceutical Education and Research (NIPER) Ahmedabad, An Institute of National Importance, Government of India, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Palaj, Opp. Air Force Station, Gandhinagar 382355, Gujarat, India. Electronic address:
Rheumatoid arthritis (RA) is a chronic inflammatory immune disease that causes synovial membrane inflammation and destruction of articular cartilage. Traditionally, methotrexate is a first-line drug for RA treatment. However, its therapeutic benefits are insufficient.
View Article and Find Full Text PDFCell Mol Life Sci
August 2024
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7FY, UK.
Heparan sulfate (HS) proteoglycans are important regulators of cellular responses to soluble mediators such as chemokines, cytokines and growth factors. We profiled changes in expression of genes encoding HS core proteins, biosynthesis enzymes and modifiers during macrophage polarisation, and found that the most highly regulated gene was Sulf2, an extracellular HS 6-O-sulfatase that was markedly downregulated in response to pro-inflammatory stimuli. We then generated Sulf2 bone marrow chimeric mice and examined inflammatory responses in antigen-induced arthritis, as a model of rheumatoid arthritis.
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