The development of several types of autoimmune disorders is well known in the course of B-cell lymphoproliferative diseases. In order to investigate whether these autoimmune diseases may target cutaneous antigens, especially those of the dermal-epidermal junction, we conducted a retrospective analysis of all cutaneous direct immunofluorescence studies performed in patients with B-cell neoplasia who presented with cutaneous lesions requiring a skin biopsy. Patients with linear deposits of immunoglobulin or C3 molecules at the dermal-epidermal junction were studied further, using immunoblotting and immunoelectron microscopy. Patients with no overt hematologic malignancies but with cutaneous lesions requiring direct immunofluorescence were studied as a control population. During the study period, the diagnosis of autoimmune blistering diseases of the dermal-epidermal junction was established in 9/102 (8.9% +/- 2%) patients with a B-cell lymphoid disorder, compared with 288/8,189 (3.5% +/- 0.04%) patients without underlying hemopathy (p < 0.01). Among the 9 patients, 7 were studied in detail. Immunologic studies demonstrated epidermolysis bullosa acquisita in 6 patients and cicatricial pemphigoid in 1. Autoimmune blistering diseases, especially epidermolysis bullosa acquisita, are part of the spectrum of autoimmune disorders associated with B-cell neoplasia.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/00005792-199907000-00003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Oral administration of astaxanthin mitigates chronological skin aging in mice.
Biosci Biotechnol Biochem
December 2024
Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
Intrinsic skin aging is a chronological decline in skin texture and function influenced largely by genetic factors. Aged skin exhibits morphological alterations, including wrinkling, dryness, and roughness, along with dysfunctional changes in the skin barrier. In this study, the in vivo anti-intrinsic aging efficacy of dietary astaxanthin extracted from Haematococcus pluvialis on the skin was evaluated using aged C57BL/6 J mice.
View Article and Find Full Text PDFControl of Epithelial Tissue Organization by mRNA Localization.
bioRxiv
December 2024
Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Article Synopsis
- mRNA is commonly localized in specific areas of mammalian cells, particularly at the dermal-epidermal junction (DEJ) in skin tissue, which is important for tissue health.
- Disrupting this localization in mice leads to changes in DEJ structure and connections between skin cells and the underlying matrix, impacting overall tissue homeostasis.
- This research highlights how localized mRNA influences the distribution of Net1 protein and RhoA activity, revealing a crucial link between mRNA positioning and epithelial tissue organization.
Evaluation of Very-High-Frequency Ultrasound Imaging Characteristics of Dermatofibroma.
Clin Cosmet Investig Dermatol
December 2024
Department of Ultrasound, Hangzhou Third People's Hospital, Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, People's Republic of China.
Background: Dermatofibroma (DF) is one of the common dermatosis, which is so challenging to diagnose that its misdiagnostic incidence is quite high. The very-high-frequency (VHF) ultrasound is particularly relevant to the diagnosis of . Herein, we analyze the sonographic features and application value of VHF ultrasound in the diagnosis of .
View Article and Find Full Text PDFA Comparative Study of Direct Immunofluorescence Patterns in Linear IgA Bullous Dermatosis Versus Dermatitis Herpetiformis.
Am J Dermatopathol
November 2024
Professor and Department Chair, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, SC.
Background: Dermatitis herpetiformis (DH) is typically characterized by granular IgA deposition in the papillary dermis on direct immunofluorescence (DIF), and linear IgA bullous dermatosis (LABD) is characterized by linear deposition of IgA along the basement membrane. Other DIF findings in both conditions may include IgG, IgM, and C3 deposition in various patterns. In cases where immunofluorescence findings are unclear, such as continuous but somewhat granular IgA deposition along the dermal-epidermal junction, additional DIF patterns may be helpful in the diagnostic process.
View Article and Find Full Text PDF[Skin fragility in autoimmune blistering diseases of the skin].
Dermatologie (Heidelb)
December 2024
Klinik für Dermatologie und Allergologie, Philipps-Universität Marburg, Marburg, Deutschland.
In many disorders, skin and/or mucosal changes are dominated by blisters, wounds, or erosions. While these changes can be observed during infective, traumatic, metabolic, or inflammatory processes, these are normally clinical hallmarks of the disruption of the cytoarchitectural stability of the skin. Several proteins, such as those located in the dermal-epidermal junction zone and forming the hemidesmosomes, or those forming epidermal desmosomes are crucial for the maintenance of skin integrity.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!