Phenytoin metabolism is best described using nonlinear (Michaelis-Menton) kinetics. When calculated pharmacokinetic values, including half life and clearance, do not correspond to measured variables, alternative reasons must be sought. We present an interesting case of phenytoin toxicity and suggest that formation of a bezoar may be one possible answer to prolonged toxicity.
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http://dx.doi.org/10.1097/00045391-199709000-00008 | DOI Listing |
Curr Environ Health Rep
January 2025
AJ Drexel Autism Institute, Drexel University, Philadelphia, USA, PA.
Purpose Of Review: Per- and polyfluoroalkyl substances (PFAS) are persistent chemicals with many modern applications, leading to widespread contamination and universal human exposure. PFAS exposure during early life is of particular concern, given susceptibility of the developing fetal and infant brain to toxic exposures. This review aims to synthesize current evidence, discuss methodological challenges, and highlight research gaps to guide future studies on the impact of PFAS on neurodevelopment.
View Article and Find Full Text PDFCell Mol Life Sci
January 2025
Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Air pollution is a global environmental health hazard associated with elevated cardiovascular morbidity and mortality. Emerging evidence suggests that exposure to various air pollutants, specifically particulate matter (PM), ultrafine particulate matter (UFPM), and diesel exhaust particles, may exacerbate myocardial ischemia-reperfusion (I/R) injury. PM exposure can directly impair cardiomyocyte survival under ischemic conditions by inducing inflammation, oxidative stress, apoptosis, and dysregulation of non-coding RNAs.
View Article and Find Full Text PDFClin Oral Investig
January 2025
Professor, Department of Biology, Faculty of Science, Dokuz Eylul University, Izmir, Tr-35340, Turkey.
Objective: This study investigated the use of oral rinse solutions formulated with boron-containing compounds, known for their antibacterial activity, as an alternative to chlorhexidine (CHX).
Material And Method: Boron nitride (BN), boric acid (BA) and sodium borate (SB) were used in the study. BN was used in nanosuspension (BN-NS) due to its low solubility in water.
Angew Chem Int Ed Engl
January 2025
University of Science and Technology of China, State Key Laboratory of Fire Science, CHINA.
Lithium metal batteries have garnered significant attention as promising energy storage solutions. However, their performance is often compromised by the risks associated with highly active metallic lithium, unrestricted electrode expansion, and excessive dendrites growth. Here we introduce an advanced lithiophilic anode substrate designed by chemically patterning technology for multiple security enhancements.
View Article and Find Full Text PDFAdv Mater
January 2025
Research Center for Translational Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.
Lysosome-targeting chimeras (LYTACs) have recently emerged as a promising therapeutic strategy for degrading extracellular and membrane-associated pathogenic proteins by hijacking lysosome-targeting receptors. However, the antitumor performance of LYTAC is limited by its insufficient tumor accumulation and nonspecific activation. Additionally, the synergistic effects of LYTACs and other therapeutic modalities are crucial.
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