We describe here one case of sporadic carcinoid of the stomach, occurring in a 65-year-old man. It is a rare, recently recognized entity, with only few cases reported in the literature. We were able to detect strong MIB-1 and p53 expression in this tumour, with 86 and 80% of tumoral cells positive, respectively. These data suggest that gastric sporadic carcinoids are a highly proliferative entity probably induced by dysregulation of p53 function.
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Advances in Management of Nonfunctional Pancreas Neuroendocrine Tumors.
Surg Clin North Am
October 2024
Department of Surgery, University of Toronto, 2075 Bayview Avenue, Toronto, ON, Canada, M4N 3M5; Susan Leslie Clinic for Neuroendocrine Tumors, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. Electronic address:
Article Synopsis
- - This article discusses the latest strategies in treating non-functional sporadic pancreas neuroendocrine tumors (NET) through surgery.
- - It highlights the importance of evaluating the biological behavior of these tumors to guide treatment decisions.
- - The article outlines specific criteria for when surgery is recommended and details the tailored surgical techniques used for neuroendocrine tumors.
Hereditary Syndromes Associated with Pancreatic and Lung Neuroendocrine Tumors.
Cancers (Basel)
May 2024
Neuroendocrine Tumor Unit, EURACAN 4 and ENETS Centre of Excellence, 1st Department of Propaedeutic Internal Medicine, Laiko General Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Article Synopsis
- * These hereditary tumors tend to occur earlier in life, can be multiple, and may also involve other tumors in different organs due to genetic mutations affecting cell growth and regulation.
- * Early detection and specialized follow-up are critical for managing these tumors, with genetic screening recommended for children and diagnostic measures starting in adolescence, necessitating a multidisciplinary approach for effective treatment.
A case of early-stage type 3 gastric neuroendocrine tumor in the upper body of the stomach: is endoscopic resection feasible?
Clin J Gastroenterol
October 2024
Pathology Division, Chiba-Ken Saiseikai Narashino Hospital, Social Welfare Organization, Saiseikai Imperial Gift Foundation, Narashino City, Chiba, Japan.
Although gastric neuroendocrine tumors (NETs) are uncommon compared with gastric carcinomas, the incidence of NETs has been recently increasing. Gastric NETs are classified into three subgroups, and among these, gastrin-independent sporadic type 3 gastric NETs have a poor prognosis because of frequent lymph node or distant metastasis. We experienced a case of an early-stage type 3 gastric NET associated with lymphovascular and submucosal invasion.
View Article and Find Full Text PDFGender Differences in Lung Neuroendocrine Tumors: A Single-Center Experience.
Neuroendocrinology
May 2024
Department of Clinical Medicine and Surgery; Endocrinology, Diabetology and Andrology Unit, Federico II University of Naples, Naples, Italy.
Introduction: Gender difference may affect lung neuroendocrine tumor (L-NET) onset, progression, and outcomes as emerged in other cancers. This study aimed to analyze gender difference in L-NET to identify potential prognostic factors, to improve patient follow-up and therapeutic strategies.
Methods: Patients with histologically confirmed L-NEN diagnosis referred to the ENETS CoE of the Endocrinology Unit, Federico II University of Naples, from 2013 to 2023, were retrospectively evaluated.
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