The maintenance of comminuted or otherwise unstable nasal bones in proper position following adequate operative reduction, may, on occasion, be a frustrating experience for both the patient and the surgeon. Migration of the fragments may compromise the aesthetic and functional results of well executed corrective nasal surgery. In this article, we will outline our successful, inexpensive approach to this occasionally challenging problem utilising an absorbable intranasal customised Surgicel bolster.
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Clin Pharmacol Ther
January 2025
Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food & Drug Administration, Silver Spring, Maryland, USA.
In response to increased illicit use of synthetic opioids, various μ-receptor antagonist formulations, with varied pharmacological characteristics, have been and are being developed. To understand how pharmacologic characteristics such as absorption rate and clearance rate affect reversal in treating community opioid overdose, we used our previously published translational opioid model. We adapted this model with in vitro receptor binding data and clinical pharmacokinetic data of three intranasal nalmefene formulations along with an intranasal naloxone formulation to study the reversal of fentanyl and carfentanil-induced respiratory depression in chronic opioid users.
View Article and Find Full Text PDFJ Plast Reconstr Aesthet Surg
November 2024
The Department of Perineal Plastic Surgery and Gender Reshaping of Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:
Objectives: To introduce a novel technique using the buried-guided suture method for suspending the alar crus to correct nostril exposure in East Asians and to investigate its safety and efficacy.
Methods: Patients with ptotic alar crus and nostril exposure at our clinic were enrolled between December 2011 and December 2023. Via an intranasal incision, the excess skin on the inner side of the nostrils was excised.
J Pharm Sci
November 2024
Riphah Institute of Pharmaceutical Sciences (RIPS), Riphah International University Faisalabad, Faisalabad, Pakistan.
Depression is a mental disorder that often comes with symptoms like irritability, rage, changes in appetite or weight, hopelessness, and loss of interest in day-to-day activities. Venlafaxine (VLF) is a medication used to treat depression. When taken orally, only about 45 % of VLF enters the systemic circulation due to liver metabolism.
View Article and Find Full Text PDFJ Ethnopharmacol
February 2025
Department of Convergence Korean Medical Science, College of Korean Medicine, Kyung Hee, Republic of Korea; Korean Medicine Digital Convergence Center (KMDC), Kyung Hee University University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea. Electronic address:
Ethnopharmacological Relevance: Essential oils from herbs, including those from Asarum sieboldii Miq., are readily absorbed through mucous membranes, explaining their widespread use in inhalation formulations. Asarum sieboldii Miq.
View Article and Find Full Text PDFAdv Ther
December 2024
Medical Affairs, Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
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