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Same Phenotype in Children with Growth Hormone Deficiency and Resistance.
Case Rep Pediatr
April 2018
University of Pavia, Piazzale Golgi 2, 27100 Pavia, Italy.
By definition, about 2.5% of children show a short stature due to several causes. Two clinical conditions are characterized by serum IGF-I low levels, idiopathic GH deficiency (IGHD), and GH insensitivity (GHI), and the phenotypic appearance of these patients may be very similar.
View Article and Find Full Text PDFIncreased neutrophil oxidative burst metabolism in systemic lupus erythematosus.
Lupus
December 2012
Division of Rheumatology, UNIFESP/EPM, São Paulo, Brazil.
Introduction: There is increased frequency of discoid lesions (2.7%) and SLE (0.5%) in patients with chronic granulomatosus disease, but the literature is still controversial about phagocyte oxidative burst in SLE patients.
View Article and Find Full Text PDFPersistence and storage of activity patterns in spiking recurrent cortical networks: modulation of sigmoid signals by after-hyperpolarization currents and acetylcholine.
Front Comput Neurosci
August 2012
Graduate Program in Cognitive and Neural Systems, Center for Adaptive Systems, Center of Excellence for Learning in Education, Science, and Technology, Center for Computational Neuroscience and Neural Technology, Boston University, Boston MA, USA.
Many cortical networks contain recurrent architectures that transform input patterns before storing them in short-term memory (STM). Theorems in the 1970's showed how feedback signal functions in rate-based recurrent on-center off-surround networks control this process. A sigmoid signal function induces a quenching threshold below which inputs are suppressed as noise and above which they are contrast-enhanced before pattern storage.
View Article and Find Full Text PDFChildhood stressful events, HPA axis and anxiety disorders.
World J Psychiatry
February 2012
Carlo Faravelli, Carolina Lo Sauro, Department of Psychology, University of Florence, 50135 Firenze, Florence, Italy.
Anxiety disorders are among the most common of all mental disorders and their pathogenesis is a major topic in psychiatry, both for prevention and treatment. Early stressful life events and alterations of hypothalamic pituitary adrenal (HPA) axis function seem to have a significant role in the onset of anxiety. Existing data appear to support the mediating effect of the HPA axis between childhood traumata and posttraumatic stress disorder.
View Article and Find Full Text PDF[Hirsutism: differential diagnosis].
Arq Bras Endocrinol Metabol
December 2006
Serviço de Endocrinologia e Metabologia, HCFMUSP, São Paulo, SP.
Hirsutism is one of the manifestations of the hyperandrogenic syndromes. A practical approach consists of dividing the hyperandrogenic syndromes into virilizing and non-virilizing, in accordance to the presence or absence of virilization symptoms. A case of a patient with hirsutism and a high basal and post-ACTH stimulation concentration of 17-OHP is presented.
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