Percutaneous closure of a patent arterial duct was performed in 58 patients. A Rashkind double umbrella was inserted in 20 patients. A supplementary double umbrella or coils were implanted in four who had residual leaks after 12 months. Three complications: embolization, haemolysis and late bacteriaemia were managed successfully without surgery. A detachable PDA coil was inserted in 38 patients. Three coils embolized and one could not be retrieved. At complete follow-up of 28 patients the duct was closed in all. Median procedure duration and fluoroscopy time was 60 min. and 12 min. respectively for double umbrella implantation, and 20 min. and 5 min. for coil insertion. Transcatheter occlusion of the patent duct is effective and carries little morbidity.
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Teach Learn Med
January 2025
Department of Education, University of Oxford, Oxford, UK.
Sexual and gender minority (SGM) identifying individuals experience worse health outcomes compared to non-SGM identifying counterparts. Representation of SGM individuals within medical schools may improve the delivery of more equitable healthcare through reducing biases and normalizing SGM presence within healthcare spaces. Our initial aim was to explore the extent to which role models may influence personal SGM identities within medical schools in the United Kingdom, using an interpretative phenomenological approach.
View Article and Find Full Text PDFComput Biol Med
December 2024
Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, PR China. Electronic address:
A number of anaplastic lymphoma kinase (ALK) inhibitors have been clinically approved, with lorlatinib, particularly as a third-generation drug, demonstrating efficacy against various drug-resistant ALK single mutations. However, continued clinical use of lorlatinib has led to the emergence of ALK double mutations conferring resistance to lorlatinib, notably ALK. TPX-0131 is a potential fourth-generation ALK inhibitor currently under development.
View Article and Find Full Text PDFRSC Adv
September 2024
Department of Physics, Faculty of Science, Kasetsart University 50 Ngamwongwan Rd, Chatuchak Bangkok 10900 Thailand
The presence of oxygen molecules (O) in biological membranes promotes lipid peroxidation of phospholipids with unsaturated acyl chains. On the other hand, cholesterol is considered to be an antioxidant molecule as it has a significant barrier effect on the permeation of O across membranes. However, a comprehensive explanation of how cholesterol affects the distribution and diffusion of O within lipid bilayers is yet to be established.
View Article and Find Full Text PDFNeuropsychologia
November 2024
Department of Neurology, Georgetown University Medical Center, Washington, DC, USA; Department of Rehabilitation Medicine, Georgetown University Medical Center, Washington, DC, USA; Research Division, MedStar National Rehabilitation Hospital, Washington, DC, USA.
Research over the past several decades has revealed that non-linguistic cognitive impairments can appear alongside language deficits in individuals with aphasia. One vulnerable cognitive domain is executive function, an umbrella term for the higher-level cognitive processes that allow us to direct our behavior towards a goal. Studies in healthy adults reveal that executive function abilities are supported by inner speech, the ability to use language silently in one's head.
View Article and Find Full Text PDFWorld J Urol
July 2024
Department of Urology, Singapore General Hospital, Singapore, 169608, Singapore.
Introduction: Stents with anti-reflux properties have been previously described in various studies but not widely adopted. We designed, constructed and tested a novel umbrella-looking anti-reflux skirt on a double J stent at the level of the ureteral orifice in a previous ex-vivo study. This study serves as a proof of concept of testing this prototype in a porcine model.
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