AI Article Synopsis
- MMPs, particularly MMP-9, are implicated in tumor invasion and spread.
- MMP-9-deficient mice, which develop normally, showed a significant reduction in metastatic colonies for B16-BL6 melanoma (45%) and Lewis lung carcinoma (59%).
- The study suggests that MMP-9 from host cells, rather than the tumor cells themselves, is crucial for tumor metastasis.
Article Abstract
Matrix metalloproteinases (MMPs) are thought to play a key role in tumor invasion and metastasis. The role of MMP-9 (gelatinase B) in tumor metastasis was examined in MMP-9-deficient mice produced by gene targeting using embryonic stem cells. MMP-9-deficient mice develop normally and are fertile. In these mice, the number of metastatic colonies of B16-BL6 melanoma cells or Lewis lung carcinoma cells that were implanted intravenously fell by 45% for B16-BL6 melanoma and 59% for Lewis lung carcinoma (p = 0.03 and p = 0.0043, respectively). Gelatin zymography showed that both tumor cell lines did not secrete MMP-9 by themselves but the host cells surrounding the tumor cells secrete MMP-9 in vivo. These results indicated that host-derived MMP-9 plays an important role in the process of tumor metastasis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1023/a:1006603723759 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!