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and canine periodontal disease: Current understanding and future directions.
Virulence
December 2025
Department of Oral Microbiology, College of Dentistry, Kyung Hee University, Seoul, Republic of Korea.
has emerged as a notable pathogen in canine periodontal disease, akin to in human periodontitis. This review examines the initial isolation, phylogenetic analysis, habitat, host range, relationships with host health status and age, and key pathogenic determinants, including fimbriae, proteases, citrullinating enzyme, and lipopolysaccharide. Control strategies discussed include polyphosphate to disrupt haeme/iron utilization, clindamycin with interferon alpha to reduce bacterial load and enhance the immune response, and a protease inhibitor.
View Article and Find Full Text PDFDosing and route of administration of clindamycin given in combination with rifampicin.
Clin Microbiol Infect
January 2025
Université Paris Cité and Université Sorbonne Paris Nord, Inserm, IAME, F-75018 Paris, France; Unité Fonctionelle de Pharmacologie, GHU Paris Seine Saint-Denis, Assistance Publique-Hôpitaux de Paris (APHP), Université Sorbonne Paris Nord, Bondy, France.
Objectives: The aim of the present study was to develop a PK interaction model of intravenous (IV) and oral clindamycin when combined with rifampicin, and to determine whether appropriate clindamycin concentrations could be achieved for different doses and administration routes (oral, intermittent and continuous infusion) of clindamycin.
Methods: Five hundred and eighteen plasma samples were prospectively obtained from 124 patients treated for bone and joint infections. Population PK analysis was performed using Monolix software.
High release of Candida albicans eDNA as protection for the scaffolding of polymicrobial biofilm formed with Staphylococcus aureus and Streptococcus mutans against the enzymatic activity of DNase I.
Braz J Microbiol
December 2024
Bioproducts Laboratory, Department of Microbiology, Institute of Biomedical Science, University of São Paulo, São Paulo, SP, Brazil.
This study aimed to determine the protective role of the high release of C. albicans extracellular DNA (eDNA) in a polymicrobial biofilm formed by S. aureus and S.
View Article and Find Full Text PDFIntestinal microbiome dysbiosis increases pulmonary colonization in mice by regulating the associated pathways.
Elife
October 2024
Department of Tuberculosis, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
Increasing researches reveal gut microbiota was associated with the development of tuberculosis (TB). How to prevent or reduce colonization in the lungs is a key measure to prevent TB. However, the data on gut microbiota preventing colonization in the lungs were scarce.
View Article and Find Full Text PDFWild birds as potential bioindicators of environmental antimicrobial resistance: A preliminary investigation.
Res Vet Sci
November 2024
Department of Veterinary Medical Sciences, Alma Mater Studiorum - University of Bologna, Via Tolara di Sopra 50, Ozzano dell'Emilia, 40064 Bologna, Italy.
Antimicrobial resistance (AMR) is an issue of global concern that includes human, animal, and environmental health. To tackle this phenomenon, a One Health approach is required through the involvement of all these interconnected elements. The environment poses challenges for investigation, but wildlife animals, not directly exposed to antibiotic treatments and interacting with their habitats, can serve as indicators of AMR contamination.
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