AI Article Synopsis
- A series of new compounds, called beta-diketone acrylate bioisosteres, were developed based on pseudomonic acid A to assess their antibacterial properties.
- These compounds were tested for their ability to inhibit a specific enzyme, isoleucyl-tRNA synthetase, in bacteria, showing promising antibacterial activity.
- Some of the most effective analogues not only demonstrated strong antibacterial effects in lab tests, but also achieved good levels in the bloodstream and were effective in a mouse model of infection.
Article Abstract
A series of beta-diketone acrylate bioisosteres 4 of pseudomonic acid A 1 have been synthesized and evaluated for their ability to inhibit bacterial isoleucyl-tRNA synthetase and act as antibacterial agents. A number of analogues have excellent antibacterial activity. Selected examples were shown to afford good blood levels and to be effective in a murine infection model.
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| http://dx.doi.org/10.1016/s0960-894x(99)00296-6 | DOI Listing |
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