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Primary malignant melanoma of the vagina: A case report of a rare disease that is difficult to diagnose.
Medicine (Baltimore)
January 2025
Department of Obstetrics and Gynecology, Dong-A University, College of Medicine, Busan, Republic of Korea.
Rationale: Malignant melanoma is a rare cancer that accounts for approximately 1% of all cancers. Primary malignant melanoma of the female genital tract accounts for approximately 3% to 7% of all malignant melanomas, and 0.3% to 0.
View Article and Find Full Text PDFAssociations of Body Mass Index and Percent Body Fat with Osteoporosis, Sarcopenia, and Osteosarcopenia: A Retrospective Study Based on Postmenopausal Women in China.
Healthcare (Basel)
December 2024
Department of Spine Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
: Alterations in the body mass index (BMI) and percent body fat (PBF) have been considered to be related to aging-induced changes in bone and muscle. This study aimed to evaluate the associations of the BMI and PBF with osteoporosis, sarcopenia, and osteosarcopenia in postmenopausal women. : A total of 342 participants who underwent musculoskeletal function assessments at the First Affiliated Hospital of Sun Yat-sen University between January 2015 and December 2022 were retrospectively screened.
View Article and Find Full Text PDFBone Turnover Markers Predict Changes in Bone Mineral Density in Men Treated with Abaloparatide: Results from ATOM.
J Bone Miner Res
January 2025
Radius Health Inc, Boston, MA, United States.
Early increases in bone turnover markers (BTMs) in response to anabolic therapy correlate with 18-month bone mineral density (BMD) increases in postmenopausal women with osteoporosis; however, this relationship has not been assessed in men. In this analysis, the correlation between changes from baseline in fasting intact serum procollagen type I N propeptide (PINP) and serum carboxy-terminal cross-linking telopeptide of type I collagen (CTX) at 1, 3, 6, and 12 months and percent increase from baseline in BMD at 12 months in men from the randomized phase 3 ATOM study (NCT03512262) were evaluated using Pearson's correlation coefficients. The uncoupling index (UI), a measure of the balance between markers of bone formation (PINP) and bone resorption (CTX), with positive UI favoring bone formation, was calculated.
View Article and Find Full Text PDFExploring weight management beliefs during the menopausal transition (ME-WEL project): A qualitative comparative study based on Health Belief Model.
Br J Health Psychol
February 2025
William James Center for Research, Ispa - Instituto Universitário, Lisboa, Portugal.
Objectives: While most women experience weight gain during the menopausal transition, a subset successfully maintains a healthy weight. This study explores the determinants influencing different weight experiences during the menopausal transition, using the Health Belief Model (HBM).
Design: Qualitative design.
Enhanced Osteoporosis Treatment via Nano Drug Coating Encapsulating GG.
ACS Appl Mater Interfaces
January 2025
Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College, Chongqing University Three Gorges Hospital, Chongqing Municipality Clinical Research Center for Geriatric Diseases, School of Medicine, Chongqing University, Chongqing 404000, China.
Osteoporosis is the most common systemic skeletal disorder, particularly associated with aging and postmenopausal women. With the growing knowledge about the gut-bone axis, the therapeutic strategies for osteoporosis have been shifted toward regulating gut microbiota to promote positive bone metabolism. Although GG (LGG) is widely reported to positively regulate bone metabolism by restoring the dysbiotic microbiome, oral administration is associated with sensitivity to gastric fluid and low bioavailability.
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