To shed some light on the physicochemical properties of the thyroid follicular colloid, we have screened retrospectively the autoradiographs of 60 human nodular goiters labeled 17 h preoperatively with 100 microCi 125I for evidence of colloid compartmentalization. In 87% (52/60) of all goiters examined, sporadic or multiple colloidal inclusions ('colloid stones') not mixing with newly labeled Tg were detected. The detailed analysis of 17 goiters revealed a mean incidence of 0.09+/-0.11 'colloid stones' of variable size per follicle ranging from 0.02+/-0.01 (10) to 0.43+/-0.09 (5) (mean values +/- S.D., number of sections examined in brackets). In this study we did not find a clear-cut association of incidence of 'colloid stones' with sex, age or nosologic group (hyperthyroid, preclinically hyperthyroid, euthyroid). The existence of different colloidal compartments as demonstrated in this and other studies is of considerable importance for thyroid function, interpretation of iodine kinetics, and studies on the role of iodine on growth and function of the thyrocytes. Different thyroidal iodine compartments could well be of functional relevance, for example in the adaptation of thyroid hormone secretion to antithyroid drugs or in severe and prolonged iodine deficiency, when very slow compartments become an important source of minimal quantities of iodine and thyroid hormone. 'Colloid stones', for example, may well explain the repeatedly observed, surprisingly large total iodine store in human endemic goiters, even in the presence of severe iodine deficiency. It is evident that the existence of multiple iodine compartments and, in particular, of particulate slow-turnover pools complicates the interpretation of total glandular iodine measurements with modern techniques such as X-ray fluorescence and positron emission tomography.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/s0300-9084(99)80093-5 | DOI Listing |
J Colloid Interface Sci
January 2025
Institute of Nuclear and New Energy Technology, Tsinghua University, Beijing 100084, China; Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education, Tsinghua University, Beijing 100084, China; Beijing Key Lab of Fine Ceramics, Tsinghua University, Beijing 100084, China. Electronic address:
Single-crystal ultrahigh-nickel LiNiCoMnO (NCM) materials are recognized for significant potential in the development of high-performance lithium-ion batteries, primarily owing to their higher energy density and superior cycling performance compared to polycrystalline counterparts. However, these materials require high calcination temperatures, suffer from significant lithium/nickel mixing, and face challenges in composition control. Although high-activity oxide precursors prepared via spray pyrolysis can reduce calcination temperatures, the smaller particle size of the resulting NCM materials intensifies interfacial side reactions.
View Article and Find Full Text PDFJ Colloid Interface Sci
January 2025
School of Materials Science and Engineering, Hefei University of Technology, Hefei 230009 China; Key Laboratory of Advanced Functional Materials and Devices of Anhui Province, Hefei University of Technology, Hefei 230009 China; China International S&T Cooperation Base for Advanced Energy and Environmental Materials & Anhui Provincial International S&T Cooperation Base for Advanced Energy Materials, Hefei University of Technology, Hefei 230009, China. Electronic address:
NbO has become a focus of research for its suitability as an anode material in sodium ion capacitors (SICs), due to its open ionic channels. The integration of NbO with reduced graphene oxide (rGO) is known to boost its electrical conductivity. However, the sluggish interfacial charge transfer kinetics and interface collapse of NbO/rGO pose challenges to its rate capability and durability.
View Article and Find Full Text PDFColloids Surf B Biointerfaces
April 2025
School of Pharmacy, Yantai University, 30# Qingquan Road, Yantai 264005, PR China. Electronic address:
Adv Colloid Interface Sci
January 2025
Department of Chemistry and CSGI, University of Florence, Via della Lastruccia 3, Sesto Fiorentino, FI 50019, Italy.
J Sci Food Agric
November 2024
School of Food and Biological Engineering, Key Laboratory for Agricultural Products Processing of Anhui Province, Hefei University of Technology, Hefei, China.
Background: Sesame paste faces issues with poor colloidal stability during storage, thereby affecting product quality and consumer experience. This study aimed to modify the proteins in sesame paste through stone milling and investigated the differences in stability produced in this environment, with the goal of addressing this issue.
Results: As the number of grinding times increased from one to three, the median diameter of sesame paste significantly decreased from 85 to 74 μm (P < 0.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!