Purpose: To examine the pattern of testicular cancer incidence by age, time period and birth cohort since 1969 in Canada.
Methods: In addition to analyses of the secular trends by age group and birth cohort separately, an age-period-cohort model and the submodels with standard Poisson assumptions were fitted to the data.
Results: The overall age-adjusted incidence of testicular cancer increased in Canada, from 2.8 per 100,000 males in 1969-71 to 4.2 in 1991-93. The younger age groups showed much higher absolute incidence rates in the recent period compared with those in the early period. Age-period-cohort modelling of data restricted to males aged 20-84 years suggested that the observed increase in testicular cancer could be largely attributed to a birth cohort effect. A steady increase in risk was observed among men born since 1945; those born between 1959 and 1968 were 2.0 (95% CI, 1.5-2.6) times as likely to develop testicular cancer as those born between 1904 and 1913.
Conclusion: The risk of testicular cancer has increased over time and changing exposure to environmental factors early in life may be responsible for this.
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| http://dx.doi.org/10.1007/BF03404502 | DOI Listing |
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