Seventeen cases (7 males and 10 females) of intracranial epidermoid tumours and one case (a male) of intracranial dermoid tumours were described. The patients with epidermoids represented 1.7% and the patients with dermoids represented 0.1% of all patients operated from January 1989 to July 1998 because of intracranial tumours. The average age of the patients with epidermoid tumours was 44.5 and ranged from 17 to 69 years whereas in patient with dermoid it was 19 years. Twelve epidermoid tumours (70.6%) and one dermoid tumour (100%) were located at the basal cisterns of the brain, i.e. 4 epidermoid tumours were located at the cerebello-pontine angle, 4--in the suprasellar region, 3 (2 epidermoid and 1 dermoid tumours)--in the parasellar region, and 2 in the retrosellar region. Four epidermoid tumours (23.5%) were found intraventricularly while only one (5.9%) located in the cerebral hemisphere. Mainly symptoms of cranial nerves (II, V, VII, VIII) dysfunction were observed among the patients. The average duration of the symptomatic period was 3 years. All operations were performed in a single stage using microneurosurgical techniques. Radical removal was possible in nine cases (50%) while in other nine cases the removal was subtotal. Two patients (11.1%) died in the postoperative period. Mean follow-up for the patients was 3.3 years. Among the patient three (16.7%) had a recurrence of the tumor and were operated on again. In 14 patients (72.2%) the results were very good and good. There was no difference of statistical significance of the results between patients with total and subtotal removal of tumours.
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J Neurooncol
January 2025
University of Virginia, Charlottesville, VA, USA.
Background: Even a gross total resection of a benign epidermoid tumor (ET) carries a high risk of recurrence. The management strategy mostly involves redo surgical excision but at a significant cost of morbidity and mortality. The role of adjuvant radiation therapies in this scenario is still undefined.
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Faculty of Computer and AI, Cairo University, Giza, Egypt.
Drug discovery and development is a challenging and time-consuming process. Laboratory experiments conducted on Vidarabine showed IC 6.97 µg∕mL, 25.
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January 2025
Institute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia. Electronic address:
The extracellular matrix (ECM) and its primary chemical components, including collagen, play a pivotal role in carcinogenesis and tumor progression. The ECM actively regulates cell proliferation, migration, and, importantly, resistance to various adverse factors. It is widely recognized as a key factor in modifying the resistance of tumor cells to various treatment modalities and cytotoxic compounds.
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Neurological Surgery, Cooper University Hospital, Camden, USA.
White epidermoid cysts are a rare type of epidermoid cyst that appears hyperintense on T1 weighted magnetic resonance imaging (MRI) and are known for their characteristic pearly white outer appearance on gross pathology. White epidermoid cysts are not common findings; therefore, this illustrative case report was written to highlight the characteristics, progression, radiological evaluation, and management of a patient who presented to our center. This case report emphasizes the importance of determining the proper diagnosis to treat and manage the condition appropriately and avoid potential future complications.
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January 2025
Department of Dentistry, Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Purpose: Carcinogenesis is characterized by the transformation of normal cells into malignant cells. Concerning the lower lip, exposure to UV radiation is the main etiological factor associated with the development of epidermoid carcinomas and actinic cheilitis. According to the hierarchical model theory, cancer development is driven by populations of cancer stem cells.
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