The reaction of amines of sodium azide with 3-perfluoroalkyl-3-fluoroprop-2-enoate, followed by hydrogenation, affords perfluoroalkylated beta-alanine analogues in very good yields. These compounds can be linked via an amide bond to produce peptide analogues such as carnosine or carcinine derivatives, which could have surfactive and complexing properties.
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Association of Prenatal Exposure to Endocrine-Disrupting Chemicals With Liver Injury in Children.
JAMA Netw Open
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Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York City, New York.
Importance: Prenatal exposures to endocrine-disrupting chemicals (EDCs) may increase the risk for liver injury in children; however, human evidence is scarce, and previous studies have not considered potential EDC-mixture effects. Furthermore, the association between prenatal EDC exposure and hepatocellular apoptosis in children has not been studied previously.
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The data herein presented show multivariate linear regressions performed to examine the association between individual serum perfluoroalkyl acids (PFAAs) [perfluorooctane sulfonic acid (PFOS); linear form of perfluorooctanoic acid (PFOA); perfluorohexane sulfonic acid (PFHxS); perfluorononanoic acid (PFNA)], and biomarkers of liver function (Sex Differences in the association between perfluoroalkyl compounds and liver function in US adolescents: analyses of NHANES 2013-2016). Data relate to male and female adolescents (ages 12-19 years) who participated to the 2013-2016 National Health and Nutrition Examination Survey. The outcome of interest was represented by changes in biomarkers of liver function, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT).
View Article and Find Full Text PDFSelective Associations of Recent Low Concentrations of Perfluoroalkyl Substances With Liver Function Biomarkers: NHANES 2011 to 2014 Data on US Adults Aged ≥20 Years.
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Independent Researcher, Dacula, Georgia (Dr Jain); West Virginia University School of Public Health, Morgantown, West Virginia (Dr Ducatman).
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Environ Int
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Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden.
Background: While it is known that perfluoroalkyl substances (PFASs) induce liver toxicity in experimental studies, the evidence of an association in humans is inconsistent.
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Amino Acids
August 1999
Laboratoire de Chimie Physique Organique et Colloïdale, Université Henri Poincaré, Faculté des Sciences, Nancy-Vandoeuvre, France.
The reaction of amines of sodium azide with 3-perfluoroalkyl-3-fluoroprop-2-enoate, followed by hydrogenation, affords perfluoroalkylated beta-alanine analogues in very good yields. These compounds can be linked via an amide bond to produce peptide analogues such as carnosine or carcinine derivatives, which could have surfactive and complexing properties.
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