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Undiagnosed AIDS in a 13-year-old boy in rural Gabon.
IDCases
October 2024
Center for Tropical Medicine, Bernhard-Nocht Institute for Tropical Medicine & I. Dept. of Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Article Synopsis
- Prevalence of HIV
- : Approximately 38.4 million people live with HIV globally, with a significant number (1.7 million) being children under 14, primarily in sub-Saharan Africa, where mother-to-child transmission is common and diagnoses are often delayed.
- Case Report
- : A 13-year-old boy from rural Gabon experienced repeated fever and fatigue for years, leading to multiple undiagnosed hospital visits. Ultimately, he was diagnosed with late-onset AIDS after serologic testing revealed HIV-1 infection.
- Importance of Early Detection
- : The case underlines the critical need for HIV testing in children and adolescents, especially in malaria-prone areas, as early diagnosis can significantly improve
Crystal size, shape, and conformational changes drive both the disappearance and reappearance of ritonavir polymorphs in the mill.
Proc Natl Acad Sci U S A
April 2024
Department of Chemical Engineering, University of Manchester, Manchester M13 9PL, United Kingdom.
Organic compounds can crystallize in different forms known as polymorphs. Discovery and control of polymorphism is crucial to the pharmaceutical industry since different polymorphs can have significantly different physical properties which impacts their utilization in drug delivery. Certain polymorphs have been reported to 'disappear' from the physical world, irreversibly converting to new ones.
View Article and Find Full Text PDFPreferential selection of viral escape mutants by CD8+ T cell 'sieving' of SIV reactivation from latency.
PLoS Pathog
November 2023
Infection Analytics Program, Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.
HIV rapidly rebounds after interruption of antiretroviral therapy (ART). HIV-specific CD8+ T cells may act to prevent early events in viral reactivation. However, the presence of viral immune escape mutations may limit the effect of CD8+ T cells on viral rebound.
View Article and Find Full Text PDFSuccessful clinical and virological outcomes of liver transplantation for HDV/HBV-related disease after long-term discontinuation of hepatitis B immunoglobulins.
Clin Transplant
June 2023
Hepatology Unit, Tor Vergata University, Rome, Italy.
Article Synopsis
- The study examines the long-term safety and effectiveness of withdrawing hepatitis B immunoglobulins (HBIg) in patients who underwent liver transplantation for hepatitis Delta and hepatitis B-related cirrhosis.
- A cohort of 16 patients who discontinued HBIg after a median of 24.5 months showed no recurrence of HDV/HBV infections during a follow-up period of over 11 years, with half developing immunity to HBV.
- The findings suggest that HBIg withdrawal is a viable strategy post-transplant and may warrant a reevaluation of existing prophylactic treatment guidelines for these patients.
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