AI Article Synopsis
- Metabotropic L-glutamate receptors play a key role in synaptic plasticity, particularly in the hippocampus, which is crucial for learning and memory.
- The new antagonist LY341495, which blocks all known metabotropic L-glutamate receptors, helps researchers understand their functions more clearly.
- The study also highlights the involvement of both established and newly identified receptor subtypes in processes like long-term potentiation and long-term depression in the hippocampus.
Article Abstract
Metabotropic L-glutamate receptors are involved in various forms of synaptic plasticity in the hippocampus. The use of a new antagonist (LY341495) that blocks all known metabotropic L-glutamate receptors in the brain, together with subtype-selective antagonists, has identified multiple roles both for cloned and novel metabotropic L-glutamate receptors in hippocampal long-term potentiation and long-term depression.
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| http://dx.doi.org/10.1016/s0959-4388(99)80044-0 | DOI Listing |
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