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The new gamma interferon (IFN-γ) algorithm for tuberculosis diagnosis in cynomolgus macaques.
PLoS One
December 2024
Office of Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Tuberculosis (TB) is the first infectious disease to be screened-out from specified pathogen-free cynomolgus macaques (Macaca fascicularis; Mf) using in human pharmaceutical testing. Being in either latent or active stage after exposure to the Mycobacterium tuberculosis complex (MTBC), the monkey gamma-interferon release assay (mIGRA) was previously introduced for early TB detection. However, a notable incidence of indeterminate results was observed.
View Article and Find Full Text PDF[Researc h progress on chemical constituents, pharmacological effects, toxicity,and heavy metal enrichment characteristics of Phytolacca plants].
Zhongguo Zhong Yao Za Zhi
August 2024
Key Laboratory of Tropical Translational Medicine of Ministry of Education, Key Laboratory of Tropical Medicinal Plant Research and Development in Hainan Province,Haikou Li Ethnic Medicine Key Laboratory, School of Pharmacy, Hainan Medical College Haikou 571199, China.
In China, the dry roots of Phytolacca acinosa or P. americana in the Phytolacca plants are listed as the traditional Chinese medicine(TCM) Phytolaccae Radix. Phytolacca plants contain triterpenoids, triterpenoid saponins, polysaccharides, antiviral proteins, flavonoids, and other chemical components.
View Article and Find Full Text PDFImproved pokeweed genome assembly and early gene expression changes in response to jasmonic acid.
BMC Plant Biol
August 2024
Department of Biology, York University, 4700 Keele St, Toronto, ON, M3J 1P3, Canada.
Background: Jasmonic acid (JA) is a phytohormone involved in regulating responses to biotic and abiotic stress. Although the JA pathway is well characterized in model plants such as Arabidopsis thaliana, less is known about many non-model plants. Phytolacca americana (pokeweed) is native to eastern North Americana and is resilient to environmental stress.
View Article and Find Full Text PDFMAP30 and luffin-α: Novel ribosome-inactivating proteins induce plant systemic resistance against plant viruses.
Pestic Biochem Physiol
April 2023
College of Plant Protection, Southwest University, Chongqing 400716, China. Electronic address:
Ribosome-inactivating proteins (RIPs) are toxic N-glycosylase that act on eukaryotic and prokaryotic rRNAs, resulting in arrest protein synthesis. RIPs are widely found in higher plant species and display strong antiviral activity. Previous studies have shown that PAP and α-MMC have antiviral activity against TMV.
View Article and Find Full Text PDFThe evolution and functional characterization of CXC chemokines and receptors in lamprey.
Dev Comp Immunol
March 2021
Lamprey Research Center, Liaoning Normal University, Dalian, 116081, China. Electronic address:
Chemokines are a large family of soluble peptides guiding cell migration in development and immune defense. They interact with chemokine receptors and are essential for the coordination of cell migration in diverse physiological processes. The CXC subfamily is one of the largest groups in the chemokine family and consists of multiple members.
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