The mathematical Beta function is shown to be an accurate planar representation of the natural human arch form defined by the spatial coordinates of the labial and buccal dental/bracket interfacing surfaces in the maxillary and mandibular arches. Graphic planar representations of the corresponding bracket base spatial coordinates of 33 popular preformed nickel titanium arch wires and bracket assemblies were superimposed on each of the relevant maxillary and mandibular natural forms. The arch forms of the preformed nickel titanium arch wires and bracket assemblies did not emulate the natural human arch form. The average mandibular natural human arch form first molar/canine width ratio is 2.38/1; the same preformed arch wire/bracket ratio is 1.87/1. These ratios for the maxillary arch are 1.92/1 and 1.54/1, respectively. The average canine width exceeded the natural canine width by 5.95 mm in the mandibular arch and 8.23 mm in the maxillary arch. The corresponding mandibular first molar and maxillary first molar widths exceeded the natural human first molar arch width by 0.84 mm and 2.68 mm, respectively. These findings have implications with respect to posttreatment stability and facial esthetics. "Round tripping" teeth resulting from subsequent change to stainless steel arch wires to restore a more natural human arch form and size may result in deleterious tissue effects.
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http://dx.doi.org/10.1016/S0889-5406(99)70297-0 | DOI Listing |
J Am Chem Soc
January 2025
Department of Chemistry, University of California, Riverside, California 92521-0403, United States.
Pseudouridine (Ψ) is the most abundant RNA modification in nature; however, not much is known about the biological functions of this modified nucleoside. Employing an unbiased quantitative proteomics method, we identified multiple candidate reader proteins of Ψ in RNA, including a cytoskeletal protein profilin-1 (PFN1). We demonstrated that PFN1 binds directly and selectively to Ψ-containing RNA.
View Article and Find Full Text PDFAdv Mater
January 2025
State Key Laboratory for Manufacturing Systems Engineering, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.
Replicating the structural and functional features of native myocardium, particularly its high-density cellular alignment and efficient electrical connectivity, is essential for engineering functional cardiac tissues. Here, novel electrohydrodynamically printed InterPore microfibrous lattices with anisotropic architectures are introduced to promote high-density cellular alignment and enhanced tissue interconnectivity. The interconnected pores in the microfibrous lattice enable dynamic, cell-mediated remodeling of fibrous hydrogels, resulting in continuous, mechanically stable tissue bundles.
View Article and Find Full Text PDFCancer Med
January 2025
Department of Pharmacology, College of Pharmacy, Jinan University, Guangzhou, China.
Background: Distinctive heterogeneity characterizes diffuse large B-cell lymphoma (DLBCL), one of the most frequent types of non-Hodgkin's lymphoma. Mitochondria have been demonstrated to be closely involved in tumorigenesis and progression, particularly in DLBCL.
Objective: The purposes of this study were to identify the prognostic mitochondria-related genes (MRGs) in DLBCL, and to develop a risk model based on MRGs and machine learning algorithms.
Cancer Med
January 2025
Centre for Public Health, Queen's University Belfast, Belfast, UK.
Background: This study investigated and compared the impact of financial toxicity (FT) on the health-related quality of life (HRQoL) and financial well-being of cancer patients and survivors in the United Kingdom (UK) and United States (US).
Methods: UK & US participants (n = 600) completed an online questionnaire that consisted of a validated FT instrument (COmprehensive Score for financial Toxicity-COST), a standardised HRQoL instrument (EQ-5D-5L) and questions related to their financial well-being. Tobit regression models and descriptive statistics plus χ tests were used to analyse the association between FT and (i) HRQoL whilst controlling for sociodemographic characteristics; and (ii) financial well-being.
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