Objective: To evaluate the accuracy and reliability of continuous measurement of jugular venous bulb hemoglobin oxygen saturation (SjvO2) with a fiberoptic catheter (SjvO(2OX)) during cardiac surgery versus simultaneous paired measurements of hemoglobin oxygen saturation by the Hemoximeter (SjVO(2HEM); Radiometer, Copenhagen, Denmark) and indirect estimations of hemoglobin oxygen saturation from measurements of partial pressure of oxygen in blood gases (SjVO(2BG)).
Design: A prospective study.
Setting: American Hellenic Educational Progressive Association General Hospital, University Hospital of Thessaloniki, Greece.
Patients: Thirty patients undergoing elective aortocoronary artery bypass surgery.
Interventions: In addition to routine pressure monitoring, a 4F fiberoptic catheter was placed in the left jugular bulb by a retrograde internal jugular vein approach and SIvO(2OX) was continuously measured. Before insertion, each catheter was calibrated in vitro.
Measurements And Main Results: One hundred twelve simultaneous paired recordings between SjvO(2OX) and SjVO2BG were performed to define the accuracy of SjVO(2OX) to SjVO(2BG). Sixty-one of 112 simultaneous paired recordings between SjvO(2OX) and SjVO(2HEM) and SjVO(2HEM) and SjVO(2BG) were performed to define the accuracy of SjvO(2OX) to the reference SjVO(2HEM) and the reliability of the SjVO(2BG) measurement to SjVO(2HEM). The fiberoptic catheter readings varied from underestimating to overestimating hemoglobin saturation by a mean of -5.35% to +9.67% and of -3.22% to +7.81% versus Blood Gas Analyzer (Ciba-Corning) and Co-Oximeter (OSM 2b Hemoximeter, Radiometer) values, respectively. The mean underestimation and overestimation of Co-Oximeter versus Blood Gas Analyzer values were -3.18% and +4.17%, respectively.
Conclusion: SjvO2 values obtained continuously from a jugular venous bulb fiberoptic catheter may give relatively accurate readings provided they are duly interpreted and errors caused by wall artifact or blood sampling are avoided.
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Plast Reconstr Surg Glob Open
January 2025
From the Department of Plastic Surgery, Jichi Medical University, Tochigi, Japan.
Background: The pathogenesis of deterministic radiation damage is not clearly understood, but it has been reported that fibroinflammatory pathways are up-regulated. We hypothesized that the number of adipose-derived stem/stromal cells (ASCs) decline after radiotherapies, preventing normalization of fibrosis and angiogenesis, resulting in chronic radiation damages that progress over time.
Methods: Dorsal skin of 8-week-old male BALB/cfC3H mice was irradiated with 10 Gy weekly for 4 weeks.
Front Mol Biosci
January 2025
Research Department, Children's Cancer Hospital Egypt, Cairo, Egypt.
Introduction: COVID-19 severity and high in-hospital mortality are often associated with severe hypoxemia, hyperlactatemia, and acidosis, yet the key players driving this association remain unclear. It is generally assumed that organ damage causes toxic acidosis, but since neutrophil numbers in severe COVID-19 can exceed 80% of the total circulating leukocytes, we asked if metabolic acidosis mediated by the glycolytic neutrophils is associated with lung damage and impaired oxygen delivery in critically ill patients.
Methods: Based on prospective mortality outcome, critically ill COVID-19 patients were divided into ICU- survivors and ICU-non-survivors.
Vet Anaesth Analg
January 2025
Department of Surgery, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, Burdur, Turkey.
Objective: To compare the sedative and physiological effects of intranasal (IN) and intramuscular (IM) delivery of detomidine in calves.
Study Design: Prospective, randomized experimental study.
Animals: A total of 20 healthy calves, aged 15.
Vet Pathol
December 2024
Pfizer Inc., Cambridge, MA.
The kidney plays an important role in iron homeostasis and mesangial cells (MCs) are phagocytic cells important for glomerular homeostasis. Sickle hemoglobin (HbS) modulators are promising clinical candidates for treatment of sickle cell disease. Although they prevent disease pathophysiology of HbS polymerization and red blood cell (RBC) sickling by increasing hemoglobin oxygen affinity, higher oxygen affinity can also cause transient tissue hypoxia with compensatory increases in erythropoiesis and subsequent increases in RBC turnover.
View Article and Find Full Text PDFJ Thorac Dis
November 2024
Department of Vascular Surgery, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, China.
Background: Patients with acute and high-risk pulmonary embolism have a high mortality rate, and the optimal treatment for these patients has still not been fully established. Although anticoagulation therapy is currently the preferred treatment for pulmonary embolism, for some patients with intermediate- or high-risk pulmonary embolism, anticoagulation therapy alone has a higher probability of long-term pulmonary hypertension and also seriously worsens the quality of life of patients. This paper mainly reports the efficacy and safety of percutaneous mechanical thrombectomy (PMT) in patients with acute medium- or high-risk pulmonary embolism in Taizhou Hospital of Zhejiang Province so as to provide some clinical basis for the treatment of such patients in the future.
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