AI Article Synopsis

  • The study examined eleven patients with chronic liver disease who tested positive for serum TTV DNA, revealing specific clinical symptoms and histopathological features.
  • Clinically, patients exhibited abnormal liver enzyme levels, particularly elevated ALT and gamma-GTP, with some experiencing persistent gamma-GTP elevation even after ALT normalization.
  • Histopathological findings included inflammation in the liver, changes in biliary epithelium, a high occurrence of fatty liver changes, and some samples showing characteristics similar to "viral" chronic hepatitis.

Article Abstract

To determine the clinical manifestations and histopathologic features of serum TTV DNA-positive chronic liver disease, we investigated eleven patients who showed serum TTV DNA alone, as detected by the polymerase chain reaction using first generation primer sets (RD primer series). Clinical manifestations were as follows: (1) biochemical abnormalities of the ALT-dominant and gamma-GTP-dominant types; (2) persistently elevated gamma-GTP despite normalization of ALT in gamma-GTP-dominant type patients; (3) association of TTV with pathogenesis of fatty liver or alcoholic liver dysfunction; and (4) response to liver-protective medicines. Histopathologic features were as follows: (1) inflammation-related cell infiltration scattered within the portal area, with distinguishable necroinflammation in the lobular region; (2) pathologic findings on biliary epithelium; (3) high incidence of steato-metamorphosis involvement; and (4) histologic characteristics undistinguishable from "viral" chronic hepatitis in some liver specimens.

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